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中文
Xubo Lin

Associate Professor
Supervisor of Doctorate Candidates:
Supervisor of Master's Candidates:


Academic Titles:医工百人特聘副研究员
Gender:Male
Alma Mater:东南大学
Degree:Doctor's Degree
School/Department:医工交叉创新研究院生物医学工程高精尖创新中心
Discipline:Biomedical Engineering
Business Address:北航柏彦大厦906 & 北航窦店园区8号楼334
E-Mail:

Honors and Titles:

2018   Outstanding Young Researcher Award (CBSB2018)

2018   北京航空航天大学“第六批青年拔尖人才计划”

2018   北京航空航天大学“医工百人人才计划”

2011   教育部博士研究生学术新人奖

2009   东南大学优秀毕业生

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林绪波,男,北航医工交叉创新研究院医工百人特聘副研究员,北京市生物医学工程高精尖创新中心研究员2018年1月底至今,博士生导师2019年7月至今


2009.09-2014.09年于东南大学生物科学与医学工程学院攻读博士学位(硕博连读,专业:生物医学工程),主要研究领域为计算纳米生物学;

2014.10-2017.11年于美国德克萨斯大学休斯顿健康科学中心医学院从事博士后研究,主要研究领域为计算膜生物物理学。


在呼吸药物纳米载体的分子设计、脂筏的动力学特性及其生物学意义、膜蛋白(Ras & LAT)的动力学特性等领域曾做出一些基础理论贡献,在Journal of the American Chemical SocietyNature CommunicationsNanoscaleNano ResearchBiophysical JournalSoft MatterFEBS LettersJournal of Physical Chemistry B/C等国际期刊上发表篇论文。部分工作曾被遴选入著名虚拟期刊Virtual Journal of Biological Physics Research及期刊副封面等。

课题组承担的科研项目:

1.国家自然科学基金青年基金(2020.01-2022.12,26万,项目负责人)

2.北航第六批青年拔尖人才计划(2018.01-2021.12,100万,项目负责人

3.膜生物学国家重点实验室开放课题(2020.01-2021.12,10万,项目负责人

4.北航医工百人人才计划启动经费(2018.01-2020.12,30万,项目负责人


课题组成员:

林绪波(2018.01-now,副研究员、博导、硕导)

林晓倩(2018.09-now,硕士生)

周龙飞(2019.09-now,硕士生)

田馥嘉(2018.09-2019.07,初级研究助理,去向:香港城市大学读博)

周世英(2018.10-2019.07,访问交流研究生,去向:扬州大学)


联系方式:

Email: linxbseu@buaa.edu.cn

微信公众号:


课题组虽年轻,但充满活力!欢迎具有生物医学工程、物理学、化学、计算机或软件、细胞生物学、分子生物学等学科理论或实验背景的学生加入我们的课题组,共同进步!


2020年博士研究生“申请考核制”招生方案(链接)。

2020年硕士研究生招生方案(链接)。 


博士后、访问学者或研究生,随时欢迎联系(长期有效)。 

本科毕业设计、本科研学计划,长期开放。


代表性的论文如下(#相同贡献,*通讯作者):

[24] Xiaoqian Lin, Xubo Lin*, Ning Gu*. Optimize Hydrophobic Nanoparticles to Better Target Lipid Rafts with Molecular Dynamics Simulations. Nanoscale, 2020, doi: 10.1039/C9NR09226A. (学生林晓倩为第一作者)

[23] Jiebo Li#, Qi Zhang#, Li Yan, Guorong Wu, Mingjun Hu*, Xubo Lin*, Kaijun Yuan*, Xueming Yang. Ultrafast Flash Energy Conductance at MXene-Surfactant Interface and Its Molecular Origins. Advanced Materials Interfaces, 2019, 6, 1901461.

[22] Siya Zhang, Xubo Lin*. Lipid Acyl Chain cis Double Bond Position Modulates Membrane Domain Registration/Anti-registration. Journal of the American Chemical Society, 2019, 141, 15884-15890. (Top期刊F1000Prime Recommended

[21] Fujia Tian, Xubo Lin*, Russell P. Valle, Yi Y. Zuo*, Ning Gu*. Poly(amidoamine) Dendrimer as a Respiratory Nanocarrier: Insights from Experiments and Molecular Dynamics Simulations. Langmuir, 2019, 35, 5364-5371. (学生田馥嘉为第一作者,遴选为期刊副封面)

[20] Xubo Lin* and Alemayehu A. Gorfe*. Understanding Membrane Domain-Partitioning Thermodynamics of Transmembrane Domains with Potential of Mean Force Calculations. Journal of Physical Chemistry B, 2019, 123(5), 1009-1016. 

[19] Yang Wang#, Cecylia Severin Lupala#, Haiguang Liu*, Xubo Lin*. Identification of Drug Binding Sites and Action Mechanisms with Molecular Dynamics Simulations. Current Topics in Medicinal Chemistry, 2018, 18, 2268-2277. (邀请综述)

[18] Xubo Lin, Hongyin Wang#, Zhichao Lou#, Meng Cao#, Zuoheng Zhang, Ning Gu*. Roles of PIP2 in the membrane binding of MIM I-BAR: insights from molecular dynamics simulations. FEBS Letters, 2018, 592, 2533-2542.

[17] Xubo Lin, Vinay Nair, Yong Zhou, Alemayehu A. Gorfe*. Membrane Potential and Dynamics in a Ternary Lipid Mixture: Insights from Molecular Dynamics Simulations. Physical Chemistry Chemical Physics, 2018, 20, 15841-15851.

[16] Xubo Lin, Alemayehu A. Gorfe*, Ilya Levental*. Protein Partitioning into Ordered Membrane Domains: Insights from Simulations. Biophysical Journal, 2018, 114, 1936-1944.

[15] Joseph H.  Lorent, Barbara Diaz-Rohrer, Xubo Lin, Kevin Spring, Alemayehu A. Gorfe, Kandice R. Levental, Ilya Levental*. Structural determinants and functional consequences of protein affinity for membrane rafts. Nature Communications, 2017, 8, 1219.  (Top期刊理论模拟部分主要贡献人)

[14] Zuoheng Zhang#, Xubo Lin#, Ning Gu*. Effects of Temperature and PEG Density on the Translocation of PEGylated Nanoparticles across Asymmetric Lipid Membrane. Colloids and Surfaces B: Biointerfaces, 2017, 160, 92-100.

[13]  Yue Zhang, Zhichao Lou, Xubo Lin, Qiwei Wang, Meng Cao, Ning Gu*. Optimizing purification process of MIM-I-BAR domain by introducing atomic force microscope and dynamics simulations. Colloids and Surfaces B: Biointerfaces, 2017, 157, 391-397.

[12]   Xubo Lin, Joseph H. Lorent, Allison D. Skinkle, Kandice R. Levental, M. Neal Waxham, Alemayehu A. Gorfe*, Ilya Levental*. Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation. Journal of Physical Chemistry B, 2016, 120, 11930-11941.

[11]   Xubo Lin#, Siya Zhang#, Hui Ding, Ilya Levental*, Alemayehu A. Gorfe*. The aliphatic chain of cholesterol modulates bilayer interleaflet coupling and domain registration. FEBS Letters, 2016, 590, 3368-3374.

[10]   Dandan Sun, Xubo Lin, Zuoheng Zhang, Ning Gu*. Impact of Shock-induced Lipid Nanobubble Collapse on a Phospholipid Membrane. Journal of Physical Chemistry C, 2016, 120, 18803-18810.

[9]   Kandice R. Levental, Joseph H. Lorent, Xubo Lin, Allison Skinkle, Michal Surma, Emily Stockenbojer, Alemayehu A. Gorfe, Ilya Levental*. Polyunsaturated lipids regulate membrane domain stability by tuning membrane order. Biophysical Journal, 2016, 110, 1800-1810.

[8]   Xubo Lin, Zhenlong Li, Alemayehu A. Gorfe*. Reversibility of the effects of peptide concentration and lipid composition on the clustering of H-Ras lipid anchors. Biophysical Journal, 2015, 109, 2467-2470.

[7]   Xubo Lin, Yi Y. Zuo, Ning Gu*. Shape Affects the Interactions of Nanoparticles with Pulmonary Surfactant. Science China Materials2015, 58, 28-37.

[6]   Xubo Lin, Ning Gu*. Surface properties of encapsulating hydrophobic nanoparticles regulate the main phase transition temperature of lipid bilayers: A simulation study. Nano Research2014, 7, 1195-1204.

[5]   Xubo Lin, Tingting Bai, Yi Y. Zuo, Ning Gu*. Promote Potential Applications of Nanoparticles as Respiratory Drug Carrier: Insights from Molecular Dynamics Simulations. Nanoscale, 2014, 6, 2759-2767.

[4]   Dandan Sun, Xubo Lin, Ning Gu*. Cholesterol Affects C60 Translocation across Lipid Bilayers. Soft Matter, 2014, 10, 2160-2168.

[3]   Xubo Lin, Changling Wang, Meng Wang, Kun Fang and Ning Gu*. Computer Simulation of the Effects of Nanoparticles' Adsorption on the Properties of Supported Lipid Bilayer. Journal of Physical Chemistry C, 2012, 116, 17960-17968.

[2]   Xubo Lin, Yang Li and Ning Gu*. Molecular Dynamics Simulations of the Interactions of Charge-neutral PAMAM Dendrimers with Pulmonary Surfactant. Soft Matter, 2011, 7, 3882-3888 (Selected by Virtual Journal of Biological Physics Research, 2011, Volume 21, Issue 8; Reported by Obesity, Fitness and Wellness Week and HighBeam Research)

[1]   Xubo Lin, Yang Li, and Ning Gu*. Nanoparticle’s Size Effect on Its Translocation across a Lipid Bilayer: A Molecular Dynamics Simulation. Journal of Computational and Theoretical Nanoscience, 2010, 7, 269-276.