孙联文，教授、博士生导师。2001年在中国协和医科大学获得医学博士学位，同年进入北京航空航天大学生物工程系（生物与医学工程学院前身）从事教学科研工作。曾担任副系主任/副院长，并曾赴德国柏林自由大学（访问学者）、英国伦敦大学学院（高级访问学者）留学。2020年获北航立德树人优秀奖。孙联文教授研究领域为力学生物学、空间生理学与医学工程。课题组基于医工交叉学科特色，主要开展失重性肌骨退化的机制及对抗措施研究，包括微重力下骨细胞力学感知/传导的变化及机制、运动/物理措施对抗肌骨退化的方法及其力学生物学机理。发表学术论文80余篇。承担国家自然科学基金面上/创新群体、973、国家重点研发计划、科技部支撑计划等项目10余项，所开展的研究入选首批中国空间站建设期工程航天医学实验领域项目，并于2023年获批2项中国空间站运营期首批科学实验项目。2016年受聘为第九届中国空间科学学会理事会常务理事、空间生命专委会副主任委员。
近五年主要论著（Recent Publications Selected）:
Jing-Yu Feng, Li-Jin Liu, Xiao Yang, Fei-Xiang Lu, Ming-Rou Zhang, Xing-Tong Wu, Lian-Wen Sun*. Rat bone responses to hindlimb unloading-reloading: Composition, BMD and mechanical properties. Acta Astronautica. 2024, 215, 689-697.
Ming-Rou Zhang, Xiao Yang, Xin-Tong Wu, Li-Jin Liu, Shou-Hui Wang, Lian-Wen Sun*, Yu-Bo Fan*. Effect of collagen fiber orientation on mechanical properties of bone and myofascia in hindlimb unloading rat. Acta Astronautica, 2023, 212: 261-269.
Fei-Xiang Lu, Shou-Hui Wang, Xing-Tong Wu, Xiao Yang, Lian-Wen Sun*, Yu-Yo Fan*, Role of myofascia in the recovery of bone loss after reloading in tail-suspended rats, Acta Astronautica, 2023, 208: 49-54.
Cong-Jin Liu, Xiao Yang*, Yan Mao, Xiao-Xue Zhang, Xin-Tong Wu, Shou-Hui Wang, Yu-Bo Fan, Lian-Wen Sun*. The alteration of advanced glycation end products and its potential role on bone loss under microgravity, Acta Astronautica, 2023, 206: 114-122.
Cong-Jin Liu, Xiao Yang*, Shou-Hui Wang, Xin-Tong Wu, Yan Mao, Jing-Wen Shi, Yu-Bo Fan, Lian-Wen Sun*. Preventing Disused Bone Loss Through Inhibition of Advanced Glycation End Products, International Journal of Molecular Sciences, 2023, 24(5): 4953.
Li-Jin Liu, Yu-Bo Fan, Xin-Tong Wu, Xiao Yang*, Lian-Wen Sun*. Comparison of stem cell characteristics between perichondral-derived stem cells and periosteal stem cells in postnatal rats. Medicine in Novel Technology and Devices, 2023, 18: 100238.
Zhuang Han, Lian-Wen Sun, Xiao Yang, Xin-Tong Wu*, Yu-Bo Fan*. A hierarchical 3d finite element model of osteocyte: the spectrin membrane skeleton in mechanical transmission. Journal of Computational Science, 2023, 67: 101947.
Yu-Hao Tong, Xiao Yang, Xin-Tong Wu, Shou-Hui Wang, Li-Jin Liu, Lian-Wen Sun*, Yu-Bo Fan*. The effect of periodic stretching on countering bone loss in hindlimb unloading rat, Acta Astronautica, 2022,190: 202-207.
Li-Jin Liu, Shuang Li, Xin-Tong Wu, Xiao Yang*, Lian-Wen Sun*. Contribution of endoplasmic reticulum stress response to the mechanosensitivity alteration in osteocytes under simulated microgravity, Acta Astronautica, 2022, 191: 522-527.
Xin-Tong Wu, Xiao Yang, Ran Tian, Ying-Hui Li, Chun-Yan Wang, Yu-Bo Fan*, Lian-Wen Sun*. Review: Cells Respond to Space Microgravity through Cytoskeleton Reorganization. The FASEB J. 2022, 36(2): e22114.
Shou-Hui Wang, Xiao Yang, Zhuang Han, Xin-Tong Wu, Yu-Bo Fan*, Lian-Wen Sun*. Changes of cortical bone pores structure and their effects on mechanical properties in tail-suspended rats. Medicine in Novel Technology and Devices, 2022, 16: 100175.
Zhuang Han, Lian-Wen Sun, Xin-Tong Wu, Xiao Yang*, Yu-Bo Fan*. Nonlinear dynamics of membrane skeleton in osteocyte. Computer Methods in Biomechanics and Biomedical Engineering, 2022, 26(3): 1-12.
RunYu Cao, Wen Xiao, Feng Pan, Ran Tian, Xin-Tong Wu*, Lian-Wen Sun*. Displacement and strain mapping for osteocytes under fluid shear stress using digital holographic microscopy and digital image correlation. Biomedical Optics Express. 2021, 12(4): 1922-33.
Shou-Hui Wang, Xiao Yang, Dong Ding, Xin-Tong Wu, Zhuang Han, Lian-Wen Sun*, Yu-Bo Fan*.The changes of bone vessels and their role in bone loss in tail-suspended rats. Acta Astronautica, 2021, 189: 368–378.
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun*, Yu-bo Fan*. Effects of advanced glycation end products on osteocytes mechanosensitivity, Biochemical and Biophysical Research Communications, 2021, 568: 151-157.
Dong Ding, Xiao Yang, Hui-Qin Luan, Xin-Tong Wu, Lian-Wen Sun*, Yu-Bo Fan*. The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes. Biochemical and Biophysical Research Communications, 2020, 530: 167-172.
Dong Ding, Xiao Yang, Hui-Qin Luan, Xin-Tong Wu, Cai He, Lian-Wen Sun*, Yu-Bo Fan*. Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes. Calcified Tissue International, 2020: 1-11.
Dietter Blottner*, Yun-Fei Huang, Gabor Trautmann, Lian-Wen Sun*. The fascia: Continuum linking bone and myofascial bag for global and local body movement control on Earth and in Space. A scoping review. REACH - Reviews in Human Space Exploration, 2019, 14-15: 100030.
Wen Xiao, Qixiang Wang, Feng Pan, Runyu Cao, Xin-Tong Wu, Lian-Wen Sun*. Adaptive frequency filtering based on convolutional neural networks in off-axis digital holographic microscopy. Biomedical Optical Express. 2019, 10(4): 1613-1626.
Xin-Tong Wu, Wen Xiao, Runyu Cao, Xiao Yang, Feng Pan, Lian-Wen Sun*, Yu-Bo Fan*. Spontaneous cellular vibratory motions of osteocytes are regulated by ATP and spectrin network. Bone, 2019, 128: 112056.
Shou-Hui Wang, Wenting Li, Xiao Yang, Yun-Fei Huang, Lian-Wen Sun*, Yu-Bo Fan. Musculoskeletal alterations of hindlimb during simulated microgravity and reloading in rats: compared by gender. Microgravity Science and Technology. 2019, 31(4): 347-355.
Dong Ding, Xiao Yang, Hui-Qin Luan, Xin-Tong Wu, Lian-Wen Sun*, Yu-Bo Fan*. The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes. Biochemical and Biophysical Research Communications, 2020, 530: 167-172.
Shou-Hui Wang, Xiao Yang, Min Wang, Yun-Fei Huang, Dieter Blottner, Lian-Wen Sun*, Yu-Bo Fan*. The role of body fluid shifts on hindlimb bone loss in tail suspended rats using a novel body fluid alteration device. Acta Astronautica. 2019, 159:1-7.
Yun-Fei Huang, Hui-Qin Luan, Lian-Wen Sun*, Shou-Hui Wang, Yu-Bo Fan*. Increased Blood Flow by Unilateral Intermittent Compression on Hindlimbs May Prevent Bone Loss. Microgravity Science and Technology, 2018, 30: 987-993.
Lian-Wen Sun, Shuang Li, Xiao Yang, Fang Pu, Hongyu Qi*, Yu-Bo Fan*. Contribution of bone micromechanical behavior beyond lamellar length scale to the macroscopic bone quality of hind limb unloading rats. Acta Astronautica. 2018, 152: 468–473.
Yun-Fei Huang, Yu-Bo Fan, Michele Salanova, Xiao Yang, Lian-Wen Sun*, Dieter Blottner. Effects of Plantar Vibration on Bone and Deep Fascia in a Rat Hindlimb Unloading Model of Disuse. Frontiers in Physiology, 2018, 9: 616.
Xiao Yang, Lian-Wen Sun*, Chengfei Du, Xin-Tong Wu, Yu-Bo Fan*. Finite element analysis of osteocytes mechanosensitivity under simulated microgravity, Microgravity Science and Technology, 2018, 30: 469-481.
Runyu Cao, Wen Xiao, Xin-Tong Wu, Lian-Wen Sun*, Feng Pan*. Quantitative observations on cytoskeleton changes of osteocytes at different cell parts using digital holographic microscopy. Biomedical Optics Express 2018, 9(1): 72-85.
专著（Book）:
Xiao Yang, Lian-Wen Sun, Xiaodu Wang*. A Closer Look at Glycation: A Potential Hotspot for Age-Related Complications and Diseases (Chapter 5: Effects of Advanced Glycation End Products (Ages) on Bone Biomechanics and Remodeling). Nova Science Publishers. 2021.3.4. ISBN: 978-1-53619-176-9.
孙联文，杨肖，吴欣童。细胞力学及力学生物学（译著，原著 Introduction to cell mechanics and mechanobiology.）,科学出版社。2023. 2. ISBN: 978-7-03-074583-5.
发明专利：
一种中空传动轴内嵌液路旋转接头与中空传动轴连接件. 杨肖，李双，何源，孙联文. ZL201911079044.7
一种双注射泵不间断供液系统. 孙联文，何源，杨肖，田昊. ZL201911059398.5.
一种模拟失重状态下大鼠体液分布的调节装置. 孙联文，王守辉，王敏，樊瑜波. ZL201610603340.2
一种单轴旋转在线剪切体外细胞培养装置. 樊瑜波，杨肖，孙联文，贡向辉. ZL201110060145.7
一种模拟失重尾吊大鼠主/被动运动训练装置的定位装置. 孙联文，谢添，樊瑜波，贡向辉. ZL200910249644.3
一种模拟失重尾吊大鼠主/被动运动训练装置. 孙联文，谢添，樊瑜波，贡向辉. ZL200810114305.X.
软件著作：
回转剪切系统控制台软件. 杨肖，何源，岑少锋，孙联文. 2019SR1131424.
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