Impact Factor:17.0

DOI number:10.1002/anie.201700317

Journal:ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Abstract:The development of ligands plays a key role and provides important innovations in homogeneous catalysis. In this context, we report a novel class of ferrocenyl phosphines for the alkoxycarbonylation of industrially important alkenes. A basic feature of our ligands is the combination of sterically hindered and amphoteric moieties on the P atoms, which leads to improved activity and productivity for alkoxycarbonylation reactions compared to the current industrial state-of-the-art ligand 1,2-bis((di-tert-butylphosphino)methyl)benzene). Advantageously, palladium catalysts with these novel ligands also enable such transformations without additional acid under milder reaction conditions. The practicability of the optimized ligand was demonstrated by preparation on >10 g scale and its use in palladium-catalyzed carbonylations on kilogram scale.

Co-author:Sang, Rui；Fang, Xianjie；Franke, Robert；Spannenberg, Anke；Neumann, Helfried；Jackstell, Ralf；Beller, Matthias*；

First Author:Dong, Kaiwu

Indexed by:Journal paper

Correspondence Author:Beller, Matthias*

Document Type:J

Volume:56

Issue:19

Page Number:5267 - 5271

Translation or Not:no

Date of Publication:2017-05-02

Included Journals:SCI

Links to published journals:https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201700317