研究方向

离子-通道工程

1. 钙通道蛋白（生物物理；调控多肽）

2. 钙离子信号（分子生理；荧光探针）

教育与工作经历

浙江大学 科仪系生物医学工程/本科

清华大学 电机系生物医学工程/硕士

Case Western Reserve University, BME/博士

Johns Hopkins University, BME and Neurosciences 博士后

清华大学 生物医学工程系 PI

北京航空航天大学 生物与医学工程学院 教授

主要学术兼职

中国生物医学工程学会 生物医学测量分会 副主任委员  

中国神经科学会 离子通道与受体分会  常务会员

中国生物物理学会 钙信号分会  委员 

科研项目

Research Grant 32371301 (PI) from NSFC, China 2024-2027

Research Grant 81971728 (PI) from NSFC, China 2020-2023

Research Grant 7191006 (PI) from BNSF, Beijing, China 2019-2021

Research Grant 21778034 (PI) from NSFC, China 2018-2021

Research Grant 31370822 (PI) from NSFC, China 2014-2017

Research Grant 7142089 (PI) from BNSF, Beijing, China 2014-2016

Research Grant 81171382 (PI) from NSFC, China 2012-2015

Research Grant 2011CB707701 (Co-PI) 973, China 2011-2015 

代表性研究论文

• Geng JL#, Yang YX#, Li BY#, Yu Z, Qiu S, Zhang W, Gao SX, Liu N, Liu Y, Wang B, Fan YB*, Xing CF* and Liu XD* (刘晓冬) (2024) Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage. Cell Reports Methods DOI: 10.1016/j.crmeth.2024.100898

  https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(24)00288-1

• Yang YX#, Geng JL#, YU Z#,et al., Li XM*, Fan YB* and Liu XD* (刘晓冬) (2022) Cytosolic peptides encoding Ca_V1 C-termini downregulate the calcium channel activity-neuritogenesis coupling. Communications Biology DOI: 10.1038/s42003-022-03438-1.

  https://www.nature.com/articles/s42003-022-03438-1

•  Geng JL#, TangYJ#, Yu Z#, Gao YM, Li WZ, Lu YT, Wang B, Zhou HM, Li P, Liu N, Wang P, Fan YB, Yang YX*, Guo ZC*, Liu XD* (刘晓冬) (2022) Chronic Ca²⁺ imaging of cortical neurons with long-term expression of GCaMP-X. eLife 11:e76691 DOI: 10.7554/eLife.76691.

  https://elifesciences.org/articles/76691

• Yang YX#, Liu N#, He Y#, Liu YX, Ge L, Zou LZ, Song S, Xiong W and Liu XD* (刘晓冬) (2018) Improved calcium sensor GCaMP-X overcomes the calcium channel perturbations induced by the calmodulin in GCaMP. Nature Communications DOI: 10.1038/s41467-018-03719-6. (Faculty of 1000)

  https://www.nature.com/articles/s41467-018-03719-6  

•  Su Q#, Hu FZ#, Liu YX#, Ge XF, Mei CL, Yu SQ, Shen AW, Zhou Q, Yan CY, Lei JL, Zhang YQ∗, Liu XD* (刘晓冬) and Wang TL∗ (2018) Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1. Nature Communications DOI: 10.1038/s41467-018-03606-0.

  https://www.nature.com/articles/s41467-018-03606-0

•  Liu N#, Yang YX#, Ge L#, Liu M, Colecraft HM and Liu XD* (刘晓冬) (2017) Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca²⁺ channels, eLife 6:e21989, DOI: 10.7554/eLife.21989.

  http://elifesciences.org/content/6/e21989

• Hu M#, Liu Y#, Wu J# and Liu XD* (刘晓冬) (2015) Influx-operated Ca²⁺ entry via PKD2-L1/PKD1-L3 channels facilitates sensory responses to polymodal transient stimuli. Cell Reports 13(4): 798-811, DOI: 10.1016/j.celrep.2015.09.041.

  https://www.cell.com/cell-reports/abstract/S2211-1247(15)01066-9

• Liu XD(刘晓冬), Yang PS, Yang W, and Yue DT* (2010) Enzyme-inhibitor-like tuning of Ca²⁺ channel connectivity with calmodulin. Nature 463(7283) 968-72. DOI:10.1038/nature08766. (Faculty of 1000)

  https://www.nature.com/articles/nature08766