贺子龙，副教授，PI，博士生导师。北航医工百人副研究员、热心肠智库专家、GPB青年编委、iMETA青年编委、国际检验医学青年编委、生物医学工程学会医检工程青年委员、中医药慢病防治工程常务委员。致力于运用多组学手段揭示人体微生物与疾病之间的相互作用以及人体传染性疾病与致病微生物之间的联系。主持及参与中国博士后面上基金项目、北航医工百人计划、北航医工卓越创新计划、北京市昌平区科学技术委员会“科技副总”项目、国家重点研发计划（骨干）、北京市科委概念验证项目（骨干）、北航青年科技创新团队（骨干）、国家自然基金面上项目（骨干）、北京市科技项目（首都临床特色诊疗技术研究）（骨干）等项目，在Nucleic Acids Research, Briefings in Bioinformatics，Microbiology Spectrum，Science of the Total Environment，Genomics, Proteomics & Bioinformatics等期刊发表SCI论文30余篇，总引用次数超1600+。主要研究方向包括1）基于宏基因组学等多组学手段研究人体微生物与疾病的关系；2）病原菌耐药组以及泛基因组研究；3）基于医学大数据的整合以及分子标记筛选等。

本实验室常年招收博士后研究员、博士研究生、硕士研究生以及本科毕业设计和暑期实践学生，有兴趣请联系：hezilong@buaa.edu.cn

目前已发表文章38篇，其中SCI期刊34篇（第一作者或通讯作者文章26篇）

第一作者或通讯作者文章

#代表并列第一作者 *代表通讯作者

1. Zeming Zhang, Yining Zhang, Qixiang Yuan, Zuoyi Wang, Yinping Ma, Peng Yin*, Zilong He* Elucidating the Human Gut Mycobiome by ITS Data. Microorganisms. 2024 (Q2:IF=4.1)

2.Shitao Lian, Yadong Liu, Songnian Hu,Chen Shen, Yinping Ma, Peng Yin* ,Zilong He*. Genomic insights on cgMLST markers, drug resistance and urease cluster of Proteus mirabilis strains. Microbiology Spectrum. 2024 (Q2:IF=3.7)

3.Yangjie Li, Danping Liu, Yanglan He, Zeming Zhang, Xueying Liang, Yijie Yan, Shuzhen Wang, Chunlei Fan, Lingna Lyu*, Zilong He*, Huiguo Ding*. The signatures and crosstalk of gut microbiome, mycobiome, and metabolites in decompensated cirrhotic patients. Frontiers in Microbiology. 2024 (Q1:IF=5.2)

4.Dai Wang , Kexin Li , Lijuan Wang , Zhongqiu Teng , Xia Luo , Hui Sun , Ying Huang , Songnian Hu , Xuefang Xu * and Zilong He*. Dissecting and tracing the gut microbiota of infants with botulism: A cross sectional and longitudinal study. Frontiers in Microbiology. 2024 (Q1:IF=5.2)

5.Ziran Wang, Danping Liu, Jingjia Zhang, Lingli Liu, Zeming Zhang, Chang Liu, Songnian Hu, Linhuan Wu, Zilong He*, Hongli Sun*. Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China. Annals of Clinical Microbiology and Antimicrobials. 2024 (Q2:IF=5.7)

6.Danping Liu, Lisheng Xie, Shitao Lian, Kexin Li, Yun Yang, Wenzhao-Wang, Songnian Hu, Shuang-Jiang Liu, Chang Liu*, Zilong He*. Anaerostipes hadrus, a butyrate-producing bacterium capable of metabolizing 5-fluorouracil. Msphere 2024 (Q2:IF=4.8)

7.Xudong Liu, Kexin Li, Yun Yang, Dingyan Cao, Xinjie Xu, Zilong He*, Wenming Wu*. Gut resistome profiling reveals high diversity and fluctuations in pancreatic cancer cohorts. Frontiers in Cellular and Infection Microbiology 2024 (Q2:IF=5.7)

8.Qianhui Zhu, Arslan Dovletgeldiyev, Chen Shen, Kexin Li, Songnian Hu, Zilong He*. Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction. Gut Pathogens 2023 (Q2: IF=4.2)

9.Qianhui Zhu, Jinrui Hu, Na Liu, Qiuhui Qi, Xiaoli Du, Zhigang Cui, Yan Sun, Yadong Liu,Songnian Hu, Linhuan Wu, Haijian Zhou*, Zilong He*, Juncai Ma*. Large-scale genomic survey and characterization of mcr genes carried by food borne Cronobacter isolates. Msystems. 2023 (Q1: IF=6.4)

10.Qianhui Zhu, Shenghan Gao, Binghan Xiao, Zilong He*, Songnian Hu*.Plasmer: an accurate and sensitive bacterial plasmid prediction tool based on machine-learning of shared k-mers and genomic features. Microbiology Spectrum. 2023 (Q1: IF=9.209)

11.Yahui Guo, Xiaojie Yu, Jixiao Wang, De Hua, Yuanhai You, Qingbo Wu, Qinglong Ji, Jianzhong Zhang, Liefei Li, Yuan Hu, Zhonghui Wu, Xiaoyue Wei, Lianqun Jin, Fanliang Meng, Yuhua Yang, Xiaofeng Hu, Lijin Long, Songnian Hu, Heyuan Qi, Juncai Ma, Wenwen Bei, Xiaomei Yan*, Haibin Wang *, Zilong He *. A Food poisoning caused by ST7 Staphylococcal aureus harboring sea gene in Hainan Province, China, Frontiers in Microbiology. 2023 (Q1:IF=6.064)

12. Xin Ma, Kexin Li, Fang Li, Jing Su, Weiwei Meng, Hui Sun, Jiazheng Sun, Yonghe Yuan, Yujia Lin, Songnian Hu, Xuefang Xu, Zilong He*.Tracing the foodborne botulism events of Clostridium botulinum in Xinjiang by using core genome sequence typing scheme,Microbiology Spectrum. 2022 (Q1: IF=9.209)

13. Na Liu, Danping Liu, Kexin Li, Songnian Hu, Zilong He*. The pan-genome analysis of Staphylococcus aureus reveals key factors influencing genomic plasticity, Microbiology Spectrum. 2022 (Q1: IF=9.209)

14. Zhuoning Tang, Sen Yang, Zilong He* Defining the baseline of pulmonary microbiota in healthy populations and influencing factors, 2022 International Conference on Gene Expression in Pneumonia and Influenza. 2022 (EI)

15. Li Wang#, Tao Yu#, Yaxin Zhu, Yingfeng Luo, Fan Dong, Xuemei Lin, Wenzhong Zhao, Zilong He*, Songnian Hu*, Zhiyang Dong*. Amplicon-based sequencing and co-occurence network analysis reveals notable differences of microbial community structure in healthy and dandruff scalps, BMC genomics. 2022 (Q2: IF=3.969)

16. Na Liu# , Xin Zheng# , Qianhui Zhu, Zilong He*, Songnian Hu* . The dissemination of NDM-1 in Acinetobacter baumannii strains, Current Microbiology. 2022 (Q4, IF: 2.19)

17. Mianzhi Yao#, Qianhui Zhu#, Jin Zou, Abebe Mekuria Shenkutie, Songnian Hu, Jiuxin Qu *, Zilong He*, Polly Hangmei Leung*. Genomic characterization of an uropathogenic Escherichia coli ST405 harboring blaCTX-M-15-encoding IncFIA-FIB plasmid, blaCTX-M-24-encoding IncI1 plasmid, and phage-like plasmid, Frontiers in Microbiology. 2022 (Q1, IF: 5.64)

18. Kexin Li#, Qianhui Zhu#, Fan Jiang#, Huixia Li, Jingying Liu, Tao Yu, Yiyang Du, Li Yang*, Zilong He*, Songnian Hu*. Monitoring microbial communities in intensive care units over one year in China, Science of the Total Environment.2021 (Q1,IF: 7.96)

19. Chen Shen#, Qianhui Zhu #, Fan Dong, Wei Wang, Bo Fan, Kexin Li,Jun Chen,Songnian Hu, Zilong He*, Chengxian Li*. Identifying two novel clusters in calcium oxalate stones with urinary tract infection using 16S rDNA sequencing, Frontiers in cellular and infection microbiology. 2021 (Q2, IF: 5.30)

20. Yu Kang#, Lina Yuan#, Xing Shi#, Yanan Chu#, Zilong He#, Xinmiao Jia, Qiang Lin, Qin Ma, Jian Wang, Jingfa Xiao, Songnian Hu, Zhancheng Gao, Fei Chen and Jun Yu. A fine-scale map of genome-wide recombination in divergent Escherichia coli population, Briefings in Bioinformatics.2020（Q1, IF:8.99）

21. Jing Zhang#, Zilong He#, JinTian Xu#, Shuting Song#, Qianhui Zhu, Guoguo Wu, Ying Guan, Xiaonong Wu, Rong Yue, Yue Wang, Tao Yu, Songnian Hu, Fuping Lu, Huitu Zhang, Semi-rational mutagenesis of an industrial Streptomyces fungicidicus strain for improved enduracidin productivity, Applied Microbiology and Biotechnology 2020.（Q1, IF:3.53）

22. Na L. Gao#, Zilong He#, Qianhui Zhu#, Puzi Jiang, Songnian Hu*, Wei-Hua Chen*, Selection for Cheaper Amino Acids Drives Nucleotide Usage at Translation Start in Eukaryotic Genes, Genomics, Proteomics & Bioinformatics 2021.（Q1, IF:6.615）

23. Le Xue#, Zilong He#, Xiaochun Bi, Wei Xu, Ting Wei, Shuangxiu Wu*, Songnian Hu*. Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng. BMC genomics 2019 (Q1, IF:3.501)

24. Yao Zhai#, Zilong He#, Yu Kang, Haiying Yu, Jianfeng Wang, Pengcheng Du, Zhao Zhang, Songnian Hu*, Zhancheng Gao*, Complete nucleotide sequence of pH11, an IncHI2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical Klebsiella pneumoniae isolate. Plasmid 2016（Q3, IF:1.732）

25.Zilong He#,Chengwei Zhang#, Wanfei Liu#, Qiang Lin, Ting Wei, Hasan AwadAljohi*, Wei-hua Chen*, Songnian Hu*, DRDB: An online date palm genomic resource database. Frontiers in plant science 2017（Q1, IF:4.298）

26.Zilong He, Huangkai Zhang, Shenghan Gao, Martin J. Lercher, Wei-Hua Chen*, Songnian Hu*, Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees. Nucleic Acids Research 2016（Q1, IF:9.202）

参与作者文章

27. Chaorong Tang#, Meng Yang#, Yongjun Fang#, Yingfeng Luo#, Shenghan Gao, Xiaohu Xiao, Zewei An, Binhui Zhou, Bing Zhang, Xinyu Tan, Hoong-Yeet Yeang, Yunxia Qin, Jianghua Yang, Qiang Lin, Hailiang Mei, Pascal Montoro, Xiangyu Long, Jiyan Qi, Yuwei Hua, Zilong He, Min Sun, Wenjie Li, Xia Zeng, Han Cheng, Ying Liu, Jin Yang, Weimin Tian, Nansheng Zhuang, Rizhong Zeng, Dejun Li, Peng He, Zhe Li, Zhi Zou, Shuangli Li, Chenji Li, Jixiang Wang, Dong Wei, Chao-Qiang Lai, Wei Luo, Jun Yu*, Songnian Hu* & Huasun Huang*, The rubber tree genome reveals new insights into rubber production and species adaptation. Nature Plant 2016（Q1, IF:10.3）

28. Shuai Wang#, Sen Wang#, Yingfeng Luo, Lihua Xiao, Xuenong Luo, Shenghan Gao, Yongxi Dou, Huangkai Zhang, Aijiang Guo, Qingshu Meng, Junling Hou, Bing Zhang, Shaohua Zhang, Meng Yang, Xuelian Meng, Hailiang Mei, Hui Li, Zilong He, Xueliang Zhu, Xinyu Tan, Xing-quan Zhu, Jun Yu, Jianping Cai, Guan Zhu, Songnian Hu* & Xuepeng Cai*, Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nature Communication 2016（Q1, IF:11.329）

29. Ting Wei, Zilong He, XinYu Tan, Xue Liu, XiaoYuan, Yingfeng Luo*, Songnian Hu*, An integrated RNA-Seq and network study reveals a complex regulation process of rice embryo during seed germination. Biochemical and Biophysical Research Communications 2015（Q2, IF:2.466）

30. Yatao Guo, Yao Zhai, Zhao Zhang, Daixi Li, Zhanwei Wang, Jingquan Li, Zilong He, Songnian Hu, Yu Kang* and Zhancheng Gao*, Complete Genomic Analysis of a Kingdom-Crossing Klebsiella variicola Isolate. Frontiers in microbiology 2018（Q1, IF:4.019）

31. Chaoran Dong#, Jiemei Chen#, Jilin Zheng#, Yiming Liang#, Tao Yu#, Yupeng Liu, Feng Gao, Jie Long, Hangyu Chen, Qianhui Zhu, Zilong He, Songnian Hu, Chuan He, Jian Lin*, Yida Tang*, Haibo Zhu*, 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease. Clinical Epigenetics 2020（Q1, IF:5.028）

32. Dai-Xi Li, Yao Zhai, Zhao Zhang, Ya-Tao Guo, Zhan-Wei Wang, Zi-Long He, Song-Nian Hu, Yu-Sheng Chen, Yu Kang, Zhan-Cheng Gao, Genetic factors related to the widespread dissemination of ST11 extensively drug-resistant carbapenemase-producing Klebsiella pneumoniae strains within hospital. Chin Med J (Engl). 2020（Q1, IF:1.585）

33. Yao Zhai, Daixi Li, Pengcheng Du, Zhao Zhang, Zilong He, Yatao Guo, Yusheng Chen, Yu Kang, Songnian Hu, Zhancheng Gao, Complete sequences of two new KPC-harboring plasmids in Klebsiella pneumoniae ST11 strains in China. J Glob Antimicrob Resist 2020 (Q2, IF:2.706)

34. Guo Guangxin, Kexin Li, Qianhui Zhu, Chunyan Zhao, Chao Li, Shun Zhou, Zilong He, Songnian Hu, Bin Xia, Yichao Ren, Improvements of immune genes and gut microbial composition of juvenile turbot (Scophthalmus maximus) with dietary oregano oil and probiotics. Aquaculture 2021 (Q1,IF: 4.242)

35.《宏基因组测序病原微生物监测生物信息学分析规范化管理专家共识》，中华检验医学杂志, 2021年9月44卷第9期，鲁辛辛，胡松年，王玫，贺子龙，杨继勇，谷丽，隋文君

36. Xu Gong, Hongwei Geng, Yun Yang, Shuyi Zhang, Zilong He, Yubo Fan, Fengyi Yin , Zhifa Zhang, Guo-Qiang Chen, Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction. METABOLIC ENGINEERING 2023 (Q1, IF:8.4)

37.《我国食品来源金黄色葡萄球菌种群结构分析》，中华流行病学杂志2023年6月第44卷第6期，郭亚慧，贺子龙，姬庆龙，周海健，孟凡亮，胡晓丰，魏销玥，马俊才，杨玉花，赵薇，龙丽瑾，王新，范佳铭，遇晓杰，张建中，华德，闫笑梅，王海滨

38.《肝外型非硬化门脉高压症的遗传易感性研究进展》，国际检验医学杂志，马文霞，贺子龙，丁惠国，吕翎娜