副教授 博士生导师 硕士生导师
电子邮箱：
所在单位：医学科学与工程学院
学历：博士研究生
在职信息：在职
张大可，男，遗传学博士
北京航空航天大学，医学科学与工程学院，副教授，中国科学院青年创新促进会会员。
工作经历:
2020年入职北京航空航天大学北京生物医学工程高精尖中心；
2018年获中国遗传学会遗传咨询分会高级遗传咨询师认证；
2016年入选中国科学院青年创新促进会；
2014年12月公派留学美国贝勒医学院分子与人类遗传系；
2009年作为助理研究员入职中科院精准基因组医学重点实验室从事基因组学研究；
2009年中国科学院北京基因组研究所（国家生物信息中心）获遗传学博士学位；
学术兼职：
中国分析测试协会生命组学专业委员会委员；
中国抗癌学会肿瘤测序与大数据分析专家委员会委员；
Innovation Medicine 执行副主编（2025年8月至今）；
BMC Medicine, 编委 (肿瘤学方向) （2023年至今）；
Cell Press合作刊The Innovation杂志组稿编辑（2020年6月至今）；
Cell Press旗下Heliyon杂志Associate Editor （Genetics Section 2022年至今）；
北航生物医学工程高精尖期刊Medicine in Novel Technology and Devices 杂志 编委；
国家消化系疾病临床医学研究中心（上海）Cancer Screening and Prevention 杂志 编委（2021-2022）。
主要研究方向:
主持及参加国自然、科技部国家“十三五”精准医学重点研发计划、863计划、973计划、国家科技支撑计划、中科院重点部署项目等十余项。主要研究方向为疾病发生、进展及治疗过程中的组织损伤或受累细胞群体的表观遗传重塑，共发表论文 52篇，其中第一作者或通讯作者论文 38篇。
研究成果(#共同一作；$共同通讯):
方向 1 人工智能与多组学—从数据解码到系统设计： 聚焦人工智能、多组学整合与单细胞/空间组学等前沿方法在生命医学中的应用创新，围绕复杂疾病分型、肿瘤异质性解析、免疫微环境刻画、预后模型构建及生物信息工具研发展开。研究兼顾综述引领与应用落地，强调AI驱动的多维数据融合、非侵入式评估和系统层面设计，为精准医学与生命科学研究提供方法学支撑。
Zhang, D., Zhang, L., Huang, T., Zhang, H., Ruan, C., Tian, C., ... & Luo, M. (2026). What’s next in life sciences: From “dark matter” decoding to system-level design. The Innovation Life, 4(1), 100199-1.
Bo, Y., Liu, B., Huang, S., Liu, Y., Deng, L., Zhang, D., and Zhang, J. (2026). Multi-seed searching algorithm for integrated codon optimization of mRNA stability and translational efficiency in vaccine design. Briefings in Bioinformatics, 27(1), bbaf047.
Li G, Zhao Y, Wang M, Fan H, Chen Y, Zhang H, Zhao Y, Zhang F, Sun L, Ma Y, Wei C, Schrodi SJ, Zhang D$, Zhang X$. Multi-omics highlights the impacts of cryptorchidism history on immune microenvironment variation in TGCT. Discov Oncol. 2025 Dec 3;17(1):38.
Wang J, Fan H, Bao Z, Li G, Wang L, Zhang D. (2025). Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution. Journal of Inflammation Research, 18:283-299.
Zhang D, Chen J, Yang BR, Yang B. (2025). Amazing helping hand: Artificial Intelligence in immunological management of liver disease. Frontiers in Immunology, 16:1679921
Fan H, Li X, Zhao Y, Song L, Sun L, Wu Z, Zhang J, Zhang H, Zhang F, Huang Y, Zhang D$, Wang L$. Decoding meningioma prognosis with multi-omics: macrophage diversity, immune-CNV interplay, and novel SPP1-targeted strategies. J Neurooncol. 2025;175(1):183–98.
Wu F, Zhang D*, Ren T. Intratumoral heterogeneity: Targeting origin vs. variations and AI-driven non-invasive assessment. The Innovation Life. 2025 Mar 3;3(2):100123
Du J, Zhao Y, Dong J, Li P, Hu Y, Fan H, Zhang F, Sun L, Zhang D$, Zhang Y$. Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer. Clinical Epigenetics. 2024 Dec 21;16(1):188.
Luo M, Yang W, Bai L, Zhang L, Huang J-W, Cao Y, Xie Y, Tong L, Zhang H, Yu L, Zhou L-W, Shi Y, Yu P, Wang Z, Yuan Z, Zhang P, Zhang Y, Ju F, Zhang H, Wang F, Cui Y, Zhang J, Jia G, Wan D, Ruan C, Zeng Y, Wu P, Gao Z, Zhao W, Xu Y, Yu G, Tian C, Jin LN, Dai J$, Xia B$, Sun B$, Chen F$, Gao Y-Z$, Wang H$, Wang B$, Zhang D$, Cao X$, Wang H$, Huang T$. Artificial intelligence for life sciences: A comprehensive guide and future trends. The Innovation Life. 2024;2(4):100105
Miao Z, Tian T, Chen W, Wang Q, Ma L, Zhang D, Xie M, Yu Z, Guo X, Bai G, Zhao S, Chen X, Wang W, Gao Y, Guo S$, Luo M$, Yuan L$, Tian C$, Wu L$, Yu G$, Zhang D$, Sun S$. Spatial resolved transcriptomics: Computational insights into gene transcription across tissue and organ architecture in diverse applications. The Innovation Life. 2024;2(4):100097.
Ma X-K, Yu Y, Huang T, Zhang D, Tian C, Tang W, Luo M, Du P, Yu G, Yang L. Bioinformatics software development: Principles and future directions. The Innovation Life. 2024;2(3):100083
Fan H, Song L, Fan J, Ma J, Li X, Zhang J, Hu J, Wu Z, Zhang D$, Wang L$. Decoding meningioma heterogeneity and neoplastic cell-macrophage interaction through single-cell transcriptome profiling across pathological grades. J Transl Med. 2023 Oct 25;21(1):751.
Zhang F, Zhang X, Zhang H, Lin D, Fan H, Guo S, An F, Zhao Y, Li J$, Schrodi SJ$, Zhang D$. Pan-precancer and cancer DNA methylation profiles revealed significant tissue specificity of interrupted biological processes in tumorigenesis. Epigenetics. 2023 Dec 31;18(1):2231222.
Li X, Fan H, Song X, Song B, Liu W, Dong R, Zhang H, Guo S, Liang H, Schrodi SJ, Fu X, Kaushal S, Ren Y$, Zhang D$. DNA methylome and transcriptome profiling reveal key electrophysiology and immune dysregulation in hypertrophic cardiomyopathy. Epigenetics. 2023;18(1):2195307.
Zhang H, Dong P, Fan H, Liang H, Zhang K, Zhao Y, Guo S, Schrodi SJ, Fan Y$, Zhang D$. Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma. Functional & Integrative Genomics. 2023 Jun;23(2):198.
Guo S, Zhang D, Wang H, An Q, Yu G, Han J, Jiang C, Huang J. Editorial: Computational and systematic analysis of multi-omics data for drug discovery and development. Front Med (Lausanne). 2023 Feb 21;10:1146896.
Chen R, Bai J, Zhang D, Chen L, Zhou Y, Xia P, Li A, Gu Y, Cui L, Schrodi SJ, Yi X. Next-generation liquid biopsy elucidates cfDNA origins from organ delineation to cellular population granularity. The Innovation Life 2023, 1(3): 100041.
Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X, Peng G, Ren X, Jiang N, Tian C, Chen Z-J. Single-cell technologies: From research to application. The Innovation 2022, 3(6): 100342.
Xie, S., Leung, A.W.S., Zheng, Z., Zhang, D., Xiao, C., Luo, R., Luo, M. and Zhang, S. Applications and potentials of nanopore sequencing in the (epi) genome and (epi) transcriptome era. The Innovation 2021, 2(4), p.100153.
方向 2 遗传与基因组学研究进展—疾病机制、变异解析与精准医学: 围绕人类遗传学、疾病基因组学和表观遗传调控开展研究，重点关注HBV感染与肝癌、肿瘤发生发展、近视、心肌病及遗传性疾病的分子机制。通过整合全基因组测序、DNA甲基化、拷贝数变异、体细胞突变和功能通路分析，揭示关键变异与疾病进展关系，并推动生物标志物发现和精准诊疗研究。
Zhang M, Zhang H, Cheng X, Wang X, Xu H, Gao X, Wu R, Zhang D$, Xia Y$ and Niu J$. Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment. Antiviral Research 2022, 204, p.105363.
Hong Y*, Zhang D*, Zhou X*, Chen A*, Abliz A*, Ba J, Wang L, Hu Q, Gong K, Guan X, Liu M, Zheng X, Lai S, Qu H, Zhao F, Hao S, Wu Z, Cai H, Hu S, Ma Y, Zhang J, Ke Y, Wang Q-F, Chen W, Zeng C. Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia. Genomics, Proteomics & Bioinformatics 2022, 20(1): 177-191.
D Deng L, Xu J, Chen W, Guo S, Steiner RD, Chen Q, Cheng Z, Xu Y, Yao B, Li X, Wang X, Deng K, Schrodi SJ, Zhang D$, Xin H$. Remediation of ABCG5-Linked Macrothrombocytopenia With Ezetimibe Therapy. Front Genet 2021, 12: 769699.
Zhang D$, Guo S, Schrodi SJ$. Mechanisms of DNA Methylation in Virus-Host Interaction in Hepatitis B Infection: Pathogenesis and Oncogenetic Properties. International Journal of Molecular Sciences. 2021; 22(18)
Zhang D$, Zhang K, Protzer U, Zeng C. HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site. J Clin Transl Hepatol 2021, 9(3): 399-408.
Wang L, Guan X, Hu Q, Wu Z, Chen W, Song L, Wang K, Tian K, Cao C, Zhang D, Ma J, Tong X, Zhang B, Zhang J, Zeng C. TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained by Smad7. Carcinogenesis 2021, 42(7): 913-923.
Zhang H, Dong P, Guo S, Tao C, Chen W, Zhao W, Wang J, Cheung R, Villanueva A, Fan J, Ding H, Schrodi S. J, Zhang D$ and Zeng C$. Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing. BMC Med.2020;18(1):200.
Chen W*, Zhang K*, Dong P*, Fanning G, Tao C, Zhang H, Guo S, Wang Z, Hong Y, Yang X, Lai S, Ding H, Zhao H, Zeng C$, Protzer U$, Zhang D$. Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer. Hepatol Int.2020;14(3):326-337.
Fan J, Li J, Guo S, Tao C, Zhang H, Wang W, Zhang Y, Zhang D$, Ding S$ and Zeng C$.Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.Clin Epigenetics.2020;12(1):56.
Ma J*, Hong Y*, Chen W, Li D, Tian K, Wang K, Yang Y, Zhang Y, Chen Y, Song L, Chen L, Zhang L, Du J, Zhang J, Wu Z$, Zhang D$ and Wang L$. High Copy-Number Variation Burdens in Cranial Meningiomas From Patients With Diverse Clinical Phenotypes Characterized by Hot Genomic Structure Changes. Front Oncol.2020;10.1382.
Zhao F*, Zhang D*, Zhou Q, Zhao F, He M, Yang Z, Su Y, Zhai Y, Yan J, Zhang G, Xue A, Tang J, Han X, Shi Y, Zhu Y, Liu T, Zhuang W, Huang L, Hong Y, Wu D, Li Y, Lu Q, Chen W, Jiao S, Wang Q, Srinivasalu N, Wen Y, Zeng C, Qu J$ and Zhou X$. Scleral HIF-1alpha is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis. EBioMedicine. 2020;57.102878.
Liu S*, Hong Y *, Cui K, Guan J, Han L, Chen W, Xu Z, Gong K, Ou Y, Zeng C, Li S, Zhang D$, Hu D$. Four-Generation Pedigree of Monozygotic Female Twins to Reveal Genetic Factors in Twinning Process by Whole-Genome Sequencing. Twin Res Hum Genet 2018, 1-8.
Li, Y, Xia, Y, Han, M, Chen, G, Zhang, D, Thasler, W.E, Protzer, U, and Ning, Q. 2017. IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection. Scientific Reports. 7, 12715.
Hu J, Xu Y, Li C, Hao J, Peng S, Chu X, Zhang D, Xu D, Meng S$. A cross-talk between Hepatitis B virus and host mRNAs confers viral adaptation to liver. Scientific Reports. 2015 Jul 17;5:10572.
Lin Z*, Gong K*, Pang B, Zeng C, Zhang D$. Birt-hogg-dubé syndrome with clear cell renal cell carcinoma in a Chinese family. Internal medicine (Tokyo, Japan) 2014, 53 (24), 2825.
Xu Z, Wu G, Li F, Bai J, Xing W, Zhang D$, Zeng C$. Positive selection signals of hepatitis B virus and their association with disease stages and viral genotypes. Infect Genet Evol 2013, 19C:176-187.
Zhang D*, Dong P*, Zhang K, Deng L, Bach C, Chen W, Li F, Protzer U, Ding H, Zeng C. Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment. BMC Microbiology 2012, 12:307.
Zhang D*, Ma S*, Zhang X*, Zhao H, Ding H, Zeng C. Prevalent HBV point mutations and mutation combinations at BCP/preC region and their association with liver disease progression. BMC Infect Dis 2010, 10:271.
Deng L, Tang X, Chen W, Lin J, Lai Z, Liu Z, Zhang D$: Scanning for genomic regions subject to selective sweeps using SNP-MaP strategy. Genomics Proteomics Bioinformatics 2010, 8(4):256-261.
Zhang D*, Chen J, Deng L, et al. Evolutionary selection associated with the multi-function of overlapping genes in the hepatitis B virus. Infect Genet Evol. Jan 2010;10(1):84-88.
Deng L, Tang X, Chen W, Lin J, Lai Z, Liu Z, Zhang D$. Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy. Genomics Proteomics Bioinformatics. 2010 Dec; 8(4): 256-261.
Deng L, Zhang D, Richards E, et al. Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human autosomes. J Genet Genomics. Dec 2009;36 (12):703-709.
方向 3 微生物组学分析—从宿主微生态到病原群体演化: 聚焦微生物组、病毒群体与病原体组学研究，涵盖眼表微生态、蜱虫病毒组、HBV准种及细菌转录组等主题。研究利用宏基因组测序、并行测序和转录组学手段，解析微生物群落结构变化、病原演化特征及宿主互作机制，为感染性疾病机制研究、微生态失衡识别和潜在诊断标志物挖掘提供依据。
Zhao F*, Zhang D*, Ge C, Zhang L, Reinach P. S, Tian X, Tao C, Zhao Z, Zhao C, Fu W, Zeng C and Chen W. Metagenomic Profiling of Ocular Surface Microbiome Changes in Meibomian Gland Dysfunction. Invest Ophthalmol Vis Sci.2020;61(8):22.
Zhang H*, Zhao F*, Hutchinson D*, Sun W, Ajami N, Lai S, Wong M, Petrosino JF, Fang J, Jiang J, Chen W, Reinach P, Qu J, Zeng C, Zhang D$, and Zhou X$. Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing Conjunctival Microbiome in Contact Lens Wearers. Invest Ophthalmol Vis Sci, 2017, 58(1): 128-136.
Xia H, Hu C, Zhang D, S Tang S, Zhang Z, Kou Z, Fan Z, Bente D, Zeng C, Li T. Metagenomic Profile of the Viral Communities in Rhipicephalus spp. Ticks from Yunnan, China. PloS One 2015 10 (3), e0121609..
Li F*, Zhang D*,$, Li Y, Jiang D, Luo S, Du N, Chen W, Deng L, Zeng C$. Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing. Clin Microbiol Infect. Epub 2014 Oct 29.
Zhang D*, Du N*, Ma S*, Hu Q, Lu G, Chen W, Zeng C$ In vitro Transcriptome Analysis of Two Chinese Isolates of Streptococcus suis Serotype 2. Genomics, Proteomics & Bioinformatics. 2014 pii: S1672-0229(14)00134-X.
