This research centers on the physiological characteristics of skin—specifically its softness, stretchability, and multimodal sensing capabilities—and integrates large deformation elasticity theory to advance micro-nanofiber sensing technologies. The goal is to emulate the mechanical signal transduction and perceptual mechanisms of biological skin. Key investigations focus on the electromechanical response mechanisms and signal decoupling models of skin-like materials and structures under large-strain and complex contact conditions, aiming to uncover the fundamental mechanisms underlying biomimetic tactile sensation generation. This work will provide multimodal tactile biomimetic skins with high bio-fidelity for applications in humanoid robotics and intelligent prosthetics.