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影响因子：4.5
DOI码：10.1039/d0qo01203c
发表刊物：Organic Chemistry Frontiers
摘要：Palladium-catalyzed alkoxycarbonylation reactions allow for the efficient conversion of widely available unsaturated compounds, CO and alcohols into the corresponding carboxylic acid derivatives. A driving force for the development of new and improved catalytic methodologies is the design and synthesis of ligands, which fine-tune the properties of the metal center. In general, alternation of the ligand backbone and substituents adjusts the electronic and steric properties of the active catalyst species to control activity and selectivity of a given catalytic process. Therefore, our group has a long-standing interest in ligand developments. In the past decade, several classes of ligands have been developed by us for palladium-catalyzed carbonylation reactions, which are summarized in this article. As an example, mono- and bidentate phosphines with heteroaromatic backbones were prepared to overcome the limitations of known catalyst systems. The common feature of all these ligands is the function of the integrated base, which acts as a proton shuttle for the formation of the palladium hydride and the rate-determining N-assisted alcoholysis. On the other hand, the basic substituent improves the durability of the catalyst via hemilabile coordination to the palladium center in the catalytic cycle.
合写作者：Ralf Jackstell；Robert Franke；Matthias Beller*
第一作者：Rui Sang；Yuya Hu；Rauf Razzaq
论文类型：期刊论文
通讯作者：Matthias Beller*
文献类型：期刊
卷号：8
期号：4
页面范围：799-811
是否译文：否
发表时间：2021-02-21
收录刊物：SCI
发布期刊链接：https://pubs.rsc.org/en/content/articlelanding/2021/qo/d0qo01203c