Screening and Optimization of Novel Antigen Polypeptides and Research on Vaccine Immune Efficacy

This direction focuses on the screening, optimization and immune efficacy improvement of novel polypeptide vaccines. With bioinformatics-based epitope prediction, polypeptide sequence modification and structural optimization technologies, high-specificity and high-immunogenicity dominant antigen polypeptides are precisely screened. Combined with adjuvant compatibility and delivery system optimization strategies, a novel polypeptide vaccine system is constructed. This research systematically explores the mechanisms by which polypeptide vaccines activate specific humoral and cellular immune responses, comprehensively evaluates vaccine immune protection efficacy, and solves the shortcomings of traditional vaccines such as insufficient safety, poor targeting and long preparation cycles, providing innovative technical solutions for immune prevention and treatment of infectious diseases and tumors.