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发表刊物：BBA - Molecular Basis of Disease
关键字：enhancer; pleiotropy; proliferation, migration, non-small cell lung cancer
摘要：Enhancers, cis-acting DNA elements for transcriptional regulation, are important regulators of cell identity and disease. However, of the hundreds of thousands of enhancers annotated in the human genome, only a few have been studied for their regulatory mechanisms and functions in cancer progression and therapeutic resistance. Here, we report the pleiotropy of one enhancer (named enh9) in both cell proliferation and migration in non- small cell lung cancer (NSCLC) cells. By integrating multi-genomic data, ERMP1 and PD-L1 were screened out as potential targets of enh9. CUT&Tag sequencing demonstrated that enh9 was involved in the genomic interactions between the transcription factor RELA and the promoters of ERMP1 and PD-L1. In addition, ERMP1 and PD-L1 were validated to be involved in cell proliferation and migration, respectively. Our study fully elucidated the function and transcriptional regulation mechanisms of enh9 in NSCLC. The exploration on enhancers is promising to provide new insights for cancer diagnosis and therapy.
合写作者：Qian Liu,Yingying Duan,Sihan Qi
第一作者：Qilin Wang,Junyou Zhang,Yanling Wen
论文类型：期刊论文
通讯作者：Chunyan Li
卷号：1870
页面范围：167015
是否译文：否
发表时间：2024-01-04
收录刊物：SCI