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发表刊物：International Journal of Molecular Sciences
关键字：mechanotransduction; osteogenesis; microgravity; mechanical stimuli; bone formation
摘要：Bones are constantly exposed to mechanical forces from both muscles and Earth’s gravity to maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms external mechanical signals such as force, fluid flow shear, and gravity into intracellular responses to achieve force adaptation. However, the underlying molecular mechanisms on the conversion from mechanical signals into bone formation has not been completely defined yet. In the present review, we provide a comprehensive and systematic description of the mechanotransduction signaling pathways induced by mechanical stimuli during osteogenesis and address the different layers of interconnections between different signaling pathways. Further exploration of mechanotransduction would benefit patients with osteoporosis, including the aging population and postmenopausal women.
合写作者：Qilin Wang,Junyou Zhang,Sihan Qi,Yingying Duan
第一作者：Zhaoshuo Liu
论文类型：期刊论文
通讯作者：Chunyan Li
是否译文：否
发表时间：2023-09-20
收录刊物：SCI