科学研究

吴欣童博士的研究主要以阐明航天员在空间失重性骨丢失的发生机制为目标，针对骨组织中的力学感受器—骨细胞的力学感知/传导机制，尤其是针对骨细胞所处力学环境、所受机械载荷复杂的特点，通过力学、光学手段与有限元方法、细胞生物学技术的结合，积极开展医工交叉研究，相关研究成果发表于医学类高水平期刊Bone、综合类高水平期刊Faseb J、医学光学类高水平期刊BOE等，并入选国家空间站首批航天医学实验项目。

科研项目

1.       国家自然科学基金青年基金，12002026，高频低幅振动载荷下的骨细胞随机共振响应规律及机理研究，2021/01-2023/12，主持

2.       空间站工程航天医学实验，****，2019/01-2021/01，主研

3.       第68批中国博士后面上科学基金，2020M680304，2020/11-2021/03，主持

4.       北京航空航天大学第12批青年拔尖人才项目，YWF-22-L-1236，主持

5.       国家自然科学基金面上项目，11472033，膜骨架spectrin在模拟微重力效应导致的骨细胞力敏感性改变中的作用，2015/01-2018/12，主研

主要发表论文

1.       Jingyu Feng, Lijin Liu, Xiao Yang, Feixiang Lu, Mingrou Zhang, Xingtong Wu*, Lianwen Sun*. Rat bone responses to hindlimb unloading-reloading: Composition, BMD and mechanical properties. Acta Astronautica. 2024, 215, 689-697

2.       Zhuang Han, Lian-Wen Sun, Xiao Yang, Xin-Tong Wu*, Yu-Bo Fan*. A hierarchical 3d finite element model of osteocyte: the spectrin membrane skeleton in mechanical transmission. Journal of Computational Science, 2023, 67: 101947

3.       XinTong Wu, Xiao Yang, Ran Tian, YingHui Li, ChunYan Wang, YuBo Fan*, LianWen Sun*. Review: Cells Respond to Space Microgravity through Cytoskeleton Reorganization. The FASEB J. 2022, 36, 2: e22114.

4.       XinTong Wu, Wen Xiao, RunYu Cao, Xiao Yang , Feng Pan, LianWen Sun*, YuBo Fan*. Spontaneous cellular vibratory motions of osteocytes are regulated by ATP and spectrin network. Bone, 2019, 128:112056. DOI: https://doi.org/10.1016/j.bone.2019.07.032

5.       RunYu Cao, Wen Xiao, Feng Pan, Ran Tian, XinTong Wu*, LianWen Sun. Displacement and strain mapping for osteocytes under fluid shear stress using digital holographic microscopy and digital image correlation. Biomedical Optics Express, 2021, 12(4):1922-1933. DOI: https://doi.org/10.1364/BOE.418418

6.       XinTong Wu, LianWen Sun*, HongYu Qi, Hao Shi, YuBo Fan*. The bio-response of osteocytes and its regulation on osteoblasts under vibration. Cell Biology International, 2016, 40(4): 397-406.

7.       XinTong Wu, LianWen Sun*, Xiao Yang, Dong Ding, Dong Han, YuBo Fan*. The potential role of spectrin network in the mechanotransduction of MLO-Y4 osteocytes. Sci Rep. 2017, 7:40940. DOI: 10.1038/srep4094.

8.       XinTong Wu, LianWen Sun*, Liang Men, YuBo Fan*. Effect of Osteocytes Subjected to Fluid Flow on Osteoblasts. IFMBE Proceedings. 2012. 39, pp. 210–213.

9.       Wen Xiao, Lu Xin, RunYu Cao, XinTong Wu, Ran Tian, LeiPing Che, LianWen Sun, Pietro Ferraro, Feng Pan. Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning. Lab on a Chip. 2021, 21:1385-1394. DOI: 10.1039/D0LC01113D

10.    RunYu Cao, Wen Xiao, XinTong Wu, LianWen Sun*, Feng Pan*. Quantitative observations on cytoskeleton changes of osteocytes at different cell parts using digital holographic microscopy. Biomedical Optics Express 2018, 9(1): 72-85.

11.    Dong Ding, Xiao Yang, HuiQin Luan, XinTong Wu, Cai He, LianWen Sun*, YuBo Fan*. Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes. Calcif Tissue Int. 2020.107(6):625-635

12.    Dong Ding, Xiao Yang, HuiQin Luan, XinTong Wu, LianWen Sun, YuBo Fan. The microgravity induces the ciliary shortening and an increased ratio of anterograde/ retrograde intraflagellar transport of osteocytes. Biochem Biophys Res Commun. 2020.530(1):167-172

13.    Xiao Yang, LianWen Sun*, XinTong Wu, Meng Liang, YuBo Fan*. Impact of shear stress and simulated microgravity on osteocytes using a new rotation cell culture device, Acta Astronautica, 2015, 116, 286-298.

14.    Wen Xiao, QiXiang Wang, Feng Pan, Runyu Cao, XinTong Wu, LianWen Sun. Adaptive frequency filtering based on convolutional neural networks in off-axis digital holographic microscopy. Biomedical Optical Express. 2019, 10 (4):1613-1626.

15.    Xiao Yang, LianWen Sun*, XinTong Wu, XiaoNan Wang, YuBo Fan*. Effect of simulated microgravity on osteocytes responding to fluid shear stress, Acta Astronautica, 2013, 84(3): 237-243.

专利

1.       孙联文，吴欣童，梁萌，杨肖；一种体外细胞共培养双流道机械力加载流动腔装置；北京航空航天大学；CN202175680U；2012.3.28

科研获奖

1.       第十三届全国生物力学大会优秀青年学者论文

2.       北京航空航天大学2017/2020年研究生优秀学术论文奖

3.       北京航空航天大学2019优秀研究生毕业生