科学研究

吴欣童博士主要聚焦于航天员空间失重性骨丢失的发生机制，围绕骨细胞的力学感知与传导机制开展研究。针对骨细胞复杂力学环境下的响应规律，融合力学、光学、人工智能与深度学习技术，以及建模仿真和细胞生物学方法，开展医工交叉研究。相关成果发表于 Bone、FASEB J、Acta Astronautica、BOE 等高水平期刊，并作为项目骨干圆满完成国家空间站神舟十六号航天医学项目。

科研项目

1.      国家自然科学基金青年基金，高频低幅振动载荷下的骨细胞随机共振响应规律及机理研究，2021/01-2023/12，负责人

2.      国家空间站航天医学实验项目，空间微重力环境下****的作用，2019/01-2024/12，项目骨干

3.      国家空间站航天医学实验项目，*微重力下生物分子****研究，2024.06-2027.06，项目骨干

4.      国家重点研发计划，代谢支持系统空间类器官研究，2025.12-2030.11，子课题参与人

5.      第68批中国博士后面上科学基金，2020/11-2021/03，负责人

6.      北京航空航天大学第12批青年拔尖人才项目，中央高校基本科研业务费，骨细胞力学感知/传导机制研究，YWF-22-L-1236，负责人

7.      国家自然科学基金面上项目，11972068，模拟微重力效应下初级纤毛变化规律及机制在骨细胞响应力学刺激中的作用研究，2020/01-2023/12，主要参与人

8.      国家自然科学基金面上项目，11472033，膜骨架spectrin在模拟微重力效应导致的骨细胞力敏感性改变中的作用，2015/01-2018/12，主要参与人

9.      中央高校基本科研业务费（敢为行动计划），ECMO体外循环中的溶血在线监测与生物力学机理研究，2024/10-2025/10，项目骨干

10.   中央高校基本科研业务费（敢为行动计划），“肌骨-血管-神经”相互作用在失重性骨质疏松发生中的力生物学机制，2024/10-2025/10，主要参与人

主要发表论文

1.       Liu, Li-Jin#, Lu, Fei-Xiang#, Yang, Xiao, Fan, Yu-Bo, Wu, Zhi-Hong, Wu, Xin-Tong* and Sun, Lian-Wen*. Synergistic Effect of IL-4 and Simulated Microgravity on Osteogenic Differentiation of Periosteal Stem Cells. 2026. Life Sci Space Res (Amst) 50, 106-112

2.       Tian Ran#, Wu Xintong#, Tan Yingjun, Ding Dong, Qu Lina, Yang Xiao, Wang Chunyan, Wang Yahao, Gong Taowan, Yin Xuemin, Li Yinghui*, Fan Yubo*, Sun Lianwen*. Primary Cilia Shortening Alters Osteocyte Mechanotransduction: Spaceflight vs. Simulated Microgravity. Acta Astronautica. 2026; 238 :608–620

3.       Dong Ding#, Ran Tian#, Xiao Yang, Zhe Ren, Zhi-Cheng Jing, Xin-Tong Wu*, Lian-Wen Sun*, The impact of ciliary length on the mechanical response of osteocytes to fluid shear stress. Nitric Oxide, 2025. 155: p. 1-11.

4.       Jingyu Feng, Lijin Liu, Xiao Yang, Feixiang Lu, Mingrou Zhang, Xingtong Wu*, Lianwen Sun*. Rat bone responses to hindlimb unloading-reloading: Composition, BMD and mechanical properties. Acta Astronautica. 2024, 215, 689-697

5.       Zhuang Han, Lian-Wen Sun, Xiao Yang, Xin-Tong Wu*, Yu-Bo Fan*. A hierarchical 3d finite element model of osteocyte: the spectrin membrane skeleton in mechanical transmission. Journal of Computational Science, 2023, 67: 101947

6.       XinTong Wu, Xiao Yang, Ran Tian, YingHui Li, ChunYan Wang, YuBo Fan*, LianWen Sun*. Review: Cells Respond to Space Microgravity through Cytoskeleton Reorganization. The FASEB J. 2022, 36, 2: e22114.

7.       RunYu Cao, Wen Xiao, Feng Pan, Ran Tian, XinTong Wu*, LianWen Sun. Displacement and strain mapping for osteocytes under fluid shear stress using digital holographic microscopy and digital image correlation. Biomedical Optics Express, 2021, 12(4):1922-1933. DOI: https://doi.org/10.1364/BOE.418418

8.       XinTong Wu, Wen Xiao, RunYu Cao, Xiao Yang, Feng Pan, LianWen Sun*, YuBo Fan*. Spontaneous cellular vibratory motions of osteocytes are regulated by ATP and spectrin network. Bone, 2019, 128:112056. DOI: https://doi.org/10.1016/j.bone.2019.07.032

9.       XinTong Wu, LianWen Sun*, HongYu Qi, Hao Shi, YuBo Fan*. The bio-response of osteocytes and its regulation on osteoblasts under vibration. Cell Biology International, 2016, 40(4): 397-406.

10.    XinTong Wu, LianWen Sun*, Xiao Yang, Dong Ding, Dong Han, YuBo Fan*. The potential role of spectrin network in the mechanotransduction of MLO-Y4 osteocytes. Sci Rep. 2017, 7:40940. DOI: 10.1038/srep4094.

11.    XinTong Wu, LianWen Sun*, Liang Men, YuBo Fan*. Effect of Osteocytes Subjected to Fluid Flow on Osteoblasts. IFMBE Proceedings. 2012. 39, pp. 210–213.

12.    Wen Xiao, Lu Xin, RunYu Cao, XinTong Wu, Ran Tian, LeiPing Che, LianWen Sun, Pietro Ferraro, Feng Pan. Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning. Lab on a Chip. 2021, 21:1385-1394. DOI: 10.1039/D0LC01113D

13.    RunYu Cao, Wen Xiao, XinTong Wu, LianWen Sun*, Feng Pan*. Quantitative observations on cytoskeleton changes of osteocytes at different cell parts using digital holographic microscopy. Biomedical Optics Express 2018, 9(1): 72-85.

14.    Dong Ding, Xiao Yang, HuiQin Luan, XinTong Wu, Cai He, LianWen Sun*, YuBo Fan*. Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes. Calcif Tissue Int. 2020.107(6):625-635

15.    Dong Ding, Xiao Yang, HuiQin Luan, XinTong Wu, LianWen Sun, YuBo Fan. The microgravity induces the ciliary shortening and an increased ratio of anterograde/ retrograde intraflagellar transport of osteocytes. Biochem Biophys Res Commun. 2020.530(1):167-172

16.    Xiao Yang, LianWen Sun*, XinTong Wu, Meng Liang, YuBo Fan*. Impact of shear stress and simulated microgravity on osteocytes using a new rotation cell culture device, Acta Astronautica, 2015, 116, 286-298.

17.    Wen Xiao, QiXiang Wang, Feng Pan, Runyu Cao, XinTong Wu, LianWen Sun. Adaptive frequency filtering based on convolutional neural networks in off-axis digital holographic microscopy. Biomedical Optical Express. 2019, 10 (4):1613-1626.

18.    Xiao Yang, LianWen Sun*, XinTong Wu, XiaoNan Wang, YuBo Fan*. Effect of simulated microgravity on osteocytes responding to fluid shear stress, Acta Astronautica, 2013, 84(3): 237-243.

19.    田然, 吴欣童, 孙联文. 空间微重力下细胞力学感知-传导的研究进展. 医用生物力学, 2024. 39(3): p. 387-392.

专利

1.       孙联文，吴欣童，梁萌，杨肖；一种体外细胞共培养双流道机械力加载流动腔装置；北京航空航天大学；CN202175680U；2012.3.28

科研获奖

1.       第十三届全国生物力学大会优秀青年学者论文

2.       北京航空航天大学2017/2020年研究生优秀学术论文奖

3.       北京航空航天大学2019优秀研究生毕业生