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    刘会生

    • 研究员 博士生导师: 研究生导师:
    • 性别:男
    • 出生日期:1973-03-20
    • 毕业院校:华中科技大学
    • 学历:博士研究生毕业
    • 学位:博士学位
    • 在职信息: 在职
    • 所在单位:北航大数据精准医疗高精尖创新中心
    • 入职时间:2017-06-01
    • 办公地点:北京航空航天大学柏彦大厦906
    • 联系方式:huishengliu@buaa.edu.cn
    • 电子邮箱:

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    个人简介:


    研究员,博士生导师。生物物理学会会员,国际神经科学学会会员, 国际干细胞研究学会会员。1995年武汉大学遗传系学士学位;1998年卫生部武汉生物制品研究所医学及免疫学硕士;2006年华中科技大学生物物理博士学位,师从徐涛院士;2005年底赴美国威斯康星大学麦迪逊校区(University of Wisconsin-Madison)进行神经科学博士后研究;2010 年任该校助理科学家(Assistant Scientist); 2015年受聘资深科学家(Staff Scientist)在美国国立卫生健康研究院(NIH)开展研究工作。2017年6月回国全职加入北京航空航天大学。研究工作主要集中在神经功能调控机制和人多能干细胞神经类疾病模型研究,探索和发现神经轴突投射、突触形成、囊泡释放、可塑性建立等神经功能的分子机制;进一步以神经性疾病病人多能干细胞为模型揭示神经发育和功能建立过程中的生理病理特征及分子机制。研究成果发表于Cell, Nature Neuroscience, Cell Stem Cell, Nature Biotechnology, eLife, PNAS, Nature Communications, Cell Reports, the Journal of Neuroscience等著名期刊这些成果不仅解答生命科学基础问题,还在医药领域具有转化和应用前景


    研究方向

    主要从事神经科学与人干细胞转化医学(神经类疾病)领域的研究。重点是发现神经细胞功能发生发展和成熟的机制,结合人多能干细胞模型,分化特异神经元,探索人神经类疾病体外干细胞模型构建和体内干细胞治疗。

    1)   神经元功能构建的分子机制:轴突投射,突触形成,囊泡释放,可塑性建立和网络构建。

    2)   人多能干细胞特异神经细胞的定向分化和功能建立。

    3)   人多能干细胞神经类疾病(缺血性脑卒中)体外模型构建和体内细胞治疗。

    4)   建立基于人多能干细胞的药物筛选平台。


    社会任职

    生物物理学会会员,神经科学学会SfN会员,国际干细胞研究学会(ISSCR)会员


    发表文章

     

    1.   Shin W, Ge L, Arpino G, Villarreal SA, Hamid E, Liu H, Zhao WD, Wen PJ, Chiang HC, Wu LG. (2018) Visualization of Membrane Pore in Live Cells Reveals a Dynamic-Pore Theory Governing Fusion and Endocytosis. Cell 173:934-945

    2.   Wu XS, Elias S, Liu H, Heureaux J, Wen PJ, Liu AP, Kozlov MM, Wu LG. (2017) Membrane Tension Inhibits Rapid and Slow Endocytosis in Secretory Cells. Biophys J 113:2406-2414.

    3.   Lu J, Zhong X, Liu H, Hao L, Huang CT, Sherafat MA, Jones J, Ayala M, Li L, Zhang SC. (2016) Generation of serotonin neurons from human pluripotent stem cells. Nature Biotechnology 34: 89-94.

    4.   Chen Y, Xiong M, Dong Y, Haberman A, Cao J, Liu H, Zhou W, Zhang SC. (2016) Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell Stem Cell 18: 817-26

    5.   Liu H#, Lu J, Chen H, Du Z and Zhang SC#. (2015) Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Scientific Report 5: 12189

    6.   Du ZW, Chen H, Liu H, Lu J, Qian K, Huang CL, Zhong X, Fan F, Zhang SC. (2015) Generation and expansion of pure motor neuron precursors from human stem cells. Nature Communications 6: 6626

    7.   Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL and Dong M. (2014) Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulium neurotoxins. PLoS Pathogen 10: e1004177.

    8.   Chen H, Qian K, Du Z, Cao J, Petersen A, Liu H, Blackbourn LW, Huang C, Errigo A, Yin Y, Lu J, Ayala M and Zhang SC. (2014) Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell 14: 796-809

    9.   Liu H*, Bai H*, Xue R, Takahashi H, Edwardson JM and Chapman ER. (2014) Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission. Nature Neuroscience 17: 670-677

    10.    Liu H#, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE and Chapman ER#. (2014) Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. eLife 3: e01524

    11.    Liu H#, Chapman ER and Dean C#. (2013) "Self" versus "non-self" connectivity dictates properties of synaptic transmission and plasticity. PLoS One 8: e62414.

    12.    Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC and Dong M. (2013) Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nature Communications 4: 1472.

    13.    Liu Y, Liu H., Sauvey C, Yao L, Zarnowska ED and Zhang SC. (2013) Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature Protocols 8: 1670-1679.

    14.    Lu J, Liu H, Huang CT, Chen H, Du Z, Liu Y, Sherafat MA and Zhang SC. (2013) Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Reports 3: 1580-1591.

    15.    Liu, Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M and Zhang SC. (2013) Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nature Biotechnology 31: 440-447.

    16.    Dean C, Liu H, Staudt T, Stahlberg MA, Vingill S, Buckers J, Kamin D, Engelhardt J, Jackson MB, Hell SW and Chapman ER. (2012) Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity. The Journal of Neuroscience 32: 5398-5413.

    17.    Dean C, Dunning FM, Liu H, Bomba-Warczak E, Martens H, Bharat V, Ahmed S and Chapman ER. (2012) Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen. Molecular Biology of the Cell 23: 1715-1727.

    18.    Xi J, Liu Y, Liu H, Chen H, Emborg ME and Zhang SC. (2012) Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 30(8):1655-63. 

    19.    Ma L, Hu B, Liu Y, Vermilyea SC, Liu H, Gao L, Sun Y, Zhang X and Zhang SC. (2012) Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell 10: 455-464.

    20.    Liu H and Zhang SC. (2011) Specification of neuronal and glial subtypes from human pluripotent stem cells. Cellular and molecular Life Science 68: 3995-4008.

    21.    Wang Z, Liu H, Gu Y and Chapman ER. (2011) Reconstituted synaptotagmin I mediate vesicle docking, priming, and fusion. The Journal of Cell Biology 195: 1159-1170.

    22.    Sun S, Suresh S, Liu H, Tepp WH, Johnson EA, Edwardson JM and Chapman ER. (2011) Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly. Cell Host & Microbe 10: 237-247.

    23.    Liu H, Dean C, Arthur CP, Dong M and Chapman ER. (2009) Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I. The Journal of Neuroscience 29: 7395-7403.

    24.    Dean C, Liu H, Dunning FM, Chang PY, Jackson MB and Chapman ER. (2009) Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nature Neuroscience 12: 767-776.

    25.    Wittenmayer N, Korber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T and Dresbach T. (2009) Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc Natl Acad Sci U S A 106: 13564-13569.

    26.    Dong M, Liu H, Tepp WH, Johnson EA, Janz R and Chapman ER. (2008) Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. Molecular Biology of the Cell 19, 5226-5237.

    27.    Chicka MC, Hui E, Liu H and Chapman ER. (2008) Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nature Structure Molecular Biology 15: 827-835.


    硕士、博士招生和博士后招聘


    1、生物,医学或其它相关专业

    2、神经科学、干细胞学、电生理技术、或脑卒中研究背景者优先;

    3乐于学习和接受新事物,有责任心和进取心,勤奋努力,有志于科学研究

    4、具有良好的团队合作精神。

     


    研究方向:

  • 主要从事神经科学与人干细胞转化医学(神经类疾病)领域的研究。重点是发现神经细胞功能发生发展和成熟的机制,结合人多能干细胞模型,分化特异神经元,探索人神经类疾病体外干细胞模型构建和体内干细胞治疗。

    1)   神经元功能构建的分子机制:轴突投射,突触形成,囊泡释放,可塑性建立和网络构建。

    2)   人多能干细胞特异神经细胞的定向分化和功能建立。

    3)   人多能干细胞神经类疾病(缺血性脑卒中)体外模型构建和体内细胞治疗。

    4)   建立基于人多能干细胞的药物筛选平台。