北京航空航天大学主页平台系统陈伟--中文主页--首页

个人简介

陈伟，医工百人副研究员，博士生导师。

本科毕业于北京航空航天大学生物工程系，于中国科学院北京基因组研究所取得遗传学博士学位。

长期致力于人类基因组学、分子细胞遗传学及群体遗传学研究，主要研究方向为解析基因组及细胞异质性变化在复杂性状产生过程中的作用。

代表性研究成果：

1、建立人类胚胎发育期体细胞突变特征谱，并发现低氧诱导因子激活导致的特异性突变模式；

2、应用单细胞组学发现局部低氧环境导致的成纤维细胞转分化在近视发生中的重要作用。

代表性论文：

(1) Xiaolei Lin^#, Yi Lei^#, Miaozhen Pan^#, Changxi Hu^#, Bintao Xie^#, Wenjing Wu, Jianzhong Su, Yating Li, Yuhan Tan, Xiaohuan Wei, Zhengbo Xue, Ruiyan Xu, Mengqi Di, Hanyu Deng, Shengcong Liu, Xingxing Yang, Jia Qu, Wei Chen*, Xiangtian Zhou*, and Fei Zhao*, Augmentation of scleral glycolysis promotes myopia through histone lactylation, Cell Metabolism, 2024, 36(3): 511-525

(2) Wei Chen^#, Hui Shi^#, Zhuojun Liu^#, Fan Yang^#, Jia Liu, Leqiang Zhang, Yajin Wu, Yuanshi Xia, Yuxuan Ou, Ruiting Li, Ting Zhang, Jiecheng Zhang, Xiaoyan Ke*, Kai Hu*, Jian Yu*, Single-cell transcriptomics reveals immune reconstitution in R/R T-ALL/LBL patients with donor-derived CD7 CAR-T therapy, Clinical Cancer Research, 2023, 29(8): 1484-1495

(3) Deng Wu#, Yunao Liu#, Wei Chen*, Jianming Shao, Pubu Zhuoma, Dexiong Zhao, Yang Yu, Tianzi Liu, Ruoxuan Yu, Yongna Gan, Baima Yuzheng, Yongshu Huang, Haikun Zhang, Xiaoman Bi, Chengcheng Tao, Shujuan Lai, Qiaoxia Luo, Dake Zhang, Hongmei Wang, Pingcuo Zhaxi, Jianqing Zhang, Jie Qiao, Changqing Zeng*, How placenta promotes the successful reproduction in high-altitude populations: a transcriptome comparison between adaptation and acclimatization, Molecular Biology and Evolution, 2022, 39 (6),

(4) Yaqiang Hong^#, Dake Zhang^#, Xiangtian Zhou^#, Aili Chen^#, Amir Abliz^#, Jian Bai, Liang Wang, Qingtao Hu, Kenan Gong, Xiaonan Guan, Mengfei Liu, Xinchang Zheng, Shujuan Lai, Hongzhu Qu, Fuxin Zhao, Shuang Hao, Zhen Wu, Hong Cai, Shaoyan Hu, Yue Ma, Junting Zhang, Yang Ke, Qianfei Wang, Wei Chen*, Changqing Zeng*; Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia, Genomics, Proteomics & Bioinformatics, 2022, 20 (1):177-191

(5) Fuxin Zhao^#; Hui Zhou^#;Wei Chen^#; Chenchen Zhao; Yangyang Zheng; Yijin Tao; Miaozhen Pan; Peter S.Reinach; Jiadi Zhua; Jianhong An; Runxia Lu; Jiang-fan Chen; Huifang Tang; Changqing Zeng; Jia Qu; Xiangtian Zhou*; Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression, Experimental Eye Research. 2021.11(212)

(6) Liang Wang^#; Xiaonan Guan^#; Qingtao Hu^#; ZhenWu^#; Wei Chen^#; Lairong Song; Ke Wang; Kaibing Tian; Chunwei Cao; Dake Zhang; Junpneg Ma; Xiangjun Tong; Bo Zhang; Juting Zhang*; Changqing Zeng C*; TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained by Smad7. Carcinogenesis. 2021.04(42):913-923.

(7) Wei Chen^#; Ke Zhang^#; Peiling Dong^#; Gregory Fanning; Chengcheng Tao; Haikun Zhang; Shicheng Guo; Zheng Wang; Yaqiang Hong; Xiaobo Yang; Shujuan Lai; Huiguo Ding; Haitao Zhao; Changqing Zeng*; Ulrike Protzer*; Dake Zhang*; Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer, Hepatology International, 2020.05 (14):326-337.

(8) Zhenglin Du^#; Liang Ma^#; Hongzhu Qu^#; Wei Chen^#; Bing Zhang^#; Xi Lu; Weibo Zhai; Xin Sheng; Yongqiao Sun; Wenjie Li; Meng Lei; Qiuhui Qi; Na Yuan; Shuo Shi; Jingyao Zeng; Jinyue Wang; Yadong Yang; Qi Liu; Yaqiang Hong; Lili Dong; Zhewen Zhang; Dong Zou; Yanqing Wang; Shuhui Song; Fan Liu; Xiangdong Fang; Hua Chen; Xin Liu; Jingfa Xiao*; Changqing Zeng*; Whole genome analysis of Chinese population and de novo assembly of a northern Han genome, Genomics Proteomics & Bioinformatics,2019.09.17(3):229-247.

(9) Hao Wu^#; Wei Chen^#; Fei Zhao^#; Qingyi Zhou; Reinach Peter S; Lili Deng; Li Ma; Shumeng Luo; Srinivasalu Nethrajeith; Miaozhen Pan; Yang Hu; Xiaomeng Pei; Jing Sun; Ran Ren; Yinghui Xiong; Zhonglou Zhou; Sen Zhang; Geng Tian; Jianhuo Fang; Lina Zhang; Jidong Lang; Deng Wu; Changqing Zeng*; Jia Qu J*; Xiangtian Zhou*; Scleral hypoxia is a target for myopia control, Proceedings of the National Academy of Sciences of the United States of America, 2018.07.24;115(30):E7091-E7100.

教育经历

[1]. 2002.9 -- 2006.7
北京航空航天大学生物工程本科学士
[2]. 2006.9 -- 2011.7
中国科学院北京基因组研究所遗传学研究生博士

工作经历

[1]. 2011.9 -- 2015.12
中国科学院北京基因组研究所助理研究员
[2]. 2016.1 -- 2020.4
中国科学院北京基因组研究所副研究员
[3]. 2020.4 -- 至今
北京航空航天大学医工交叉创新研究院副研究员

研究方向