陈建安 / Kinon Chen

个人简介 / Profile

陈建安，博士，北京航空航天大学生物与医学工程学院副教授、博士生导师、硕士生导师，北航“卓越百人计划”引进人才。博士毕业于美国南加州大学，曾在美国南加州大学、加拿大英属哥伦比亚大学 ICORD、英国利兹大学等机构从事博士后和访问研究工作。

Dr. Kinon Chen is an Associate Professor and PhD/MSc supervisor at the School of Biological Science and Medical Engineering, Beihang University. He received his PhD in Biomedical Engineering from the University of Southern California and has conducted research at the University of Southern California, the University of British Columbia/ICORD, and the University of Leeds.

研究方向 / Research Directions

课题组面向脊髓损伤、神经修复、脊柱侧弯及个体化治疗等重要医学问题，结合生物力学、医学影像、有限元建模、人工智能、图像处理、生物信息学/组学分析、组织学、电生理学、动物行为学、康复工程和生物材料等方法，开展从疾病机制、动物模型、自动化定量评估到个体化治疗策略设计的交叉研究。

The group works on spinal cord injury, neural repair, scoliosis, and personalized treatment, integrating biomechanics, medical imaging, finite element modeling, artificial intelligence, image processing, bioinformatics/omics, histology, electrophysiology, animal behavioral analysis, rehabilitation engineering, and biomaterials.

主要研究方向包括：

1. 脊髓损伤机制、精准评估与再髓鞘修复
   Spinal cord injury mechanisms, precision evaluation, and remyelination repair

2. 脊髓/脊柱生物力学、体内应力与有限元建模
   Spinal and spinal-cord biomechanics, in vivo stress, and finite element modeling

3. 人工智能、医学影像、图像处理与生物信息学/组学分析
   Artificial intelligence, medical imaging, image processing, and bioinformatics/omics

4. 青少年特发性脊柱侧弯个体化支具与康复优化
   Personalized bracing and rehabilitation optimization for adolescent idiopathic scoliosis

5. 生物材料、水凝胶与神经修复微环境调控
   Biomaterials, hydrogels, and neural repair microenvironment modulation

招生信息 / Prospective Students

课题组长期招收硕士、博士研究生及国际学生，欢迎具有生物医学工程、力学、机械工程、计算机/人工智能、医学影像、生物信息学、神经科学、基础医学、康复医学、材料科学等背景的同学联系申请。课题可偏实验、偏计算建模/人工智能，或结合两者开展医工交叉研究。

The group welcomes applications from MSc, PhD, and international students with backgrounds in biomedical engineering, mechanics, mechanical engineering, computer science/AI, medical imaging, bioinformatics, neuroscience, basic medicine, rehabilitation medicine, biomaterials, or related areas. Projects may be experimental, computational/modeling-oriented, AI-oriented, or interdisciplinary.

联系方式 / Contact

Email: 09738@buaa.edu.cn

代表性论文 / Representative Publications

* Equal contribution.

1. Tian L, Liu J, Li R, Sun Z, Cao X, Li L, Zhang G, Wang Z, Lei T, Lu Y, Zhang J, Yao S, Jiang L, Plunet W, So WF, Chen K*, Wenjie Ren*. Combined Blast Wave and Carbon Monoxide Poisoning Cause Synergistic Brain Injury in a Mouse Model of Coal Mine Gas Explosions. Exp Neurology. Accepted.
   

2. Wu Y, Wang F, He Y, Zhang Y, Zeng Y, Zheng F, Wei Z, Tian S*, Chen K*, Sun B*, Sun Y*. A Biomechanical Optimized Zr58Cu25Al14Nb3 Bulk Metallic Glass Dental Implant Improves Peri-implant Stress Distribution and Bone Quality Under Physiological Loading. BMEMat. In press.

3. Zou Z*, Kang S*, Chen K. Dermal Sinus in Children: Epidemiology, Diagnosis, and Management of a Retrospective Cohort. J Neurosurg Pediatr. 2026;37(5):393–401.

4. Liu J*, Huang Z*, Chen K*, Li R, Huang Z, Lin J, Jiang H, Liu J, Zhu Q. Histopathological Insights into Demyelination and Remyelination After Spinal Cord Injury in Non-human Primates. Neurosci Bull. 2025;41(8):1429–1447.

5. Li X, He Y, Chen F, Tong X, Fan Y, Langzhou Y, Liu J, Chen K. Automated Quantification of Axonal and Myelin Changes in Contusion, Dislocation, and Distraction Spinal Cord Injuries: Insights into Targeted Remyelination and Axonal Regeneration. Brain Res Bull. 2025;221:111193.

6. Zou Z*, Kang S*, Hou Y, Chen K. Pediatric spinal cord injury with radiographic abnormality: the Beijing experience. Spine J. 2023;23(3):403–411.

7. Wang J, Zhang H, Ji J, Wang L, Lv W, He Y, Li X, Feng G, Chen K. A histological study of atherosclerotic characteristics in age-related macular degeneration. Heliyon. 2022;8:e08973.

8. Zou Z, Teng A, Wu X, Zhang H, Huang L, Luo X, Chen K. Pediatric spinal cord injury without radiographic abnormality: the Beijing experience. Spine. 2021;46(20):E1083–E1088.

9. He Y, Guo Y, Wang J, Lv W, Li X, Chen K. The posterior eye with age-related macular degeneration has isotropic and nonlinear viscoelastic properties. J Mech Behav Biomed Mater. 2021;114:104207.

10. Guo Y, Hu H, Wang J, Zhang M, Chen K. Walking function after cervical contusion and distraction spinal cord injuries in rats. J Exp Neurosci. 2019;13:1179069519869615.

11. Wang J*, Zhang M*, Guo Y, Hu H, Chen K. Quantification of surviving neurons after contusion, dislocation, and distraction spinal cord injuries using automated methods. J Exp Neurosci. 2019;13:1179069519869617.

12. Zhang ZH, Pan MX, Cai JT, Weiland JD, Chen K. Viscoelastic properties of the posterior eye of normal subjects, patients with age-related macular degeneration, and pigs. J Biomed Mater Res A. 2018;106:2151–2157.

13. Chen K*, Marsh BC*, Cowan M*, Al’Joboori YD, Gigout S, Smith CC, Messenger N, Gamper N, Schwab ME, Ichiyama RM. Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats. Exp Neurol. 2017;292:135–144.

14. Chen K, Liu J, Assinck P, Bhatnagar T, Streijger F, Zhu Q, Dvorak MF, Kwon BK, Tetzlaff W, Oxland TR. Differential histopathological and behavioral outcomes eight weeks after rat spinal cord injury by contusion, dislocation, and distraction mechanisms. J Neurotrauma. 2016;33(18):1667–1684.

15. Chen K, Weiland JD. Discovery of retinal elastin and its possible role in age-related macular degeneration. Ann Biomed Eng. 2014;42(3):678–684.

16. Chen K, Rowley AP, Weiland JD, Humayun MS. Elastic properties of human posterior eye. J Biomed Mater Res A. 2014;102(6):2001–2007.

17. Chen K, Weiland JD. Relationship between vitreous temperature and posterior vitreous detachment. J Mech Behav Biomed Mater. 2013;26:54–58.

18. Chen K, Weiland JD. Mechanical characteristics of the porcine retina in low temperatures. Retina. 2012;32(4):844–847.

19. Chen K, Weiland JD. Mechanical properties of orbital fat and its encapsulating connective tissue. J Biomech Eng. 2011;133(6):064505.

20. Chen K, Weiland JD. Anisotropic and inhomogeneous mechanical characteristics of the retina. J Biomech. 2010;43(7):1417–1421.

21. Chen K, Rowley AP, Weiland JD. Elastic properties of porcine ocular posterior soft tissues. J Biomed Mater Res A. 2010;93(2):634–645.

22. Chen K, Fata B, Einstein DR. Characterization of the highly nonlinear and anisotropic vascular tissues from experimental inflation data: a validation study toward the use of clinical data for in-vivo modeling and analysis. Ann Biomed Eng. 2008;36(10):1668–1680.

主要科研项目 / Major Research Grants

1. 北京市自然科学基金委员会，市基金-昌平联合基金（培育项目），L2604037，脊髓损伤异质区域降解主导型原位水凝胶构建及时空修复机制研究，2026.7–2029.6。

2. 北京市科学技术委员会，首都科技创新券项目（XM20250009-C、XM20250008-C、XM20240019-C、XM20240016-C 等）。

3. 国家外国专家局，外国专家项目，H20240202，脊髓损伤机制与个性化治疗的跨学科创新研究及国际合作，2024.1–2025.12。

4. 国家自然科学基金委员会，面上项目，12172032，基于人脊髓非线性粘弹性及其有限元模型重建脊髓损伤过程的诊断技术研究，2022.1–2025.12。

5. 国家自然科学基金委员会，面上项目，81771347，临床相关的挫伤、剪切伤和牵拉伤胸脊髓损伤大鼠模型的建立及分析研究，2018.1–2021.12。

6. 北京航空航天大学，青年拔尖人才支持计划，YWF-17-BJ-Y-78，脊髓损伤的机制与治疗基础研究，2017.6–2021.12。

7. 北京市自然科学基金青年科学基金项目，7154215，健康人眼以及眼睛黄斑变性病人眼的粘弹性能研究，2015.1–2016.12。

8. 北京航空航天大学，“卓越百人计划”启动基金，2014.2–。