曹芳芳，国家级高层次青年人才，长期从事仿生材料在生物医学领域的应用以及益生菌疗法的临床转化，主要提出了仿生纳米酶对益生菌仿生编辑的策略。以第一/通讯作者在Nature Nanotechnology、Science Advances、Angewandte Chemie International Edition（4篇）、Advanced Materials（2篇）、ACS Nano（2篇）和Advanced Science等国际权威期刊发表论文19篇，其中入选ESI高被引论文4篇，热点论文1篇；授权国际及中国专利3项；申请新加坡卫生科学局认证保健品1项；主持新加坡国家医学基金项目（约170万RMB）、国家自然科学基金优秀青年科学基金项目（海外）等；担任英国皇家化学会期刊Nanoscale Horizons青年编委等。课题组网站：https://www.nanoprobio.com/

欢迎具有合成生物学/化学材料/生物医学背景的博士后、博士/硕士研究生、联合培养研究生加入本研究团队一起从事研究工作。（有意向者将申请材料发送至联系人邮箱fangfangcao@buaa.edu.cn，邮件标题注明“博士后/博士研究生/硕士研究生应聘+本人姓名+毕业院校”）

代表性论文

1. Fangfang Cao, Lulu Jin, Yong Gao, Yuan Ding, Hongyang Wen, Zhefeng Qian, Chenyin Zhang, Liangjie Hong, Huang Yang, Jiaojiao Zhang, Zongrui Tong, Weilin Wang*, Xiaoyuan Chen*, Zhengwei Mao*. Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis. Nat. Nanotechnol. 2023, 18, 617. (Hot paper)

2. Fangfang Cao^†, Lulu Jin^†, Chenyin Zhang, Yong Gao, Zhefeng Qian, Hongyang Wen, Sisi Yang, Ziqiang Ye, Liangjie Hong, Huang Yang, Zongrui Tong, Liang Cheng, Yuan Ding, Weilin Wang, Guocan Yu*, Zhengwei Mao*, Xiaoyuan Chen*. Engineering clinically relevant probiotics with switchable “nano-promoter” and “nano-effector” for precise tumor therapy. Adv. Mater. 2023, 36, 2304257.

3. Fangfang Cao, Lu Zhang, Yawen You, Lirong Zheng, Jinsong Ren*, Xiaogang Qu*. An enzyme-mimicking single-atom catalyst as an efficient multiple reactive oxygen and nitrogen species scavenger for sepsis management. Angew. Chem. Int. Ed. 2020, 59, 5108. (Highly cited paper)

4. Fangfang Cao, Lu Zhang, Huan Wang, Yawen You, Ying Wang*, Nan Gao, Jinsong Ren*, Xiaogang Qu*. Defect-rich adhesive nanozymes as efficient “antibiotics” for enhanced bacterial inhibition. Angew. Chem. Int. Ed. 2019, 58, 16236. (Highly cited paper)

5. Meiqi Cheng, Xinyang Yu, Shaolong Qi, Kai Yang, Meixin Lu, Fangfang Cao*, Guocan Yu*. Development of organ targeting lipid nanoparticles with low immunogenicity and its application in the treatment of pulmonary fibrosis. Angew. Chem. Int. Ed. 2024, 63, e202407398.

6. Yongfang Zheng^†,*, Xinyu Zhang^†, Mingyi Jiang, Fangfang Cao^†,*, Qing You^†,*, Xiaoyuan Chen*. Development and Applications of D-Amino Acid Derivatives-based Metabolic Labeling of Bacterial Peptidoglycan. Angew. Chem. Int. Ed. 2024, 63, e202319400.

7. Yining Chen^†, Tianshu Zou^†, Gaoying Xin, Xin Liu, Yunan Yang, Liqi Wei, Biao Zhang, Pengcheng Yu, Yiping Ren, Yanlin Feng, Rui Chen*, Fangfang Cao*, Xiaoyuan Chen*, Yan Cheng*. Oxygen-independent synchronized ROS generation and hypoxia prodrug activation with Z-scheme heterostructure sonosensitizer. Adv. Mater. 2024, 36, 2307929.

8. Chunxiong Zheng^†, Qingguo Zhong^†, Ke Yi, Huimin Kong, Fangfang Cao*, Chenya Zhuo, Yanteng Xu, Run Shi, Enguo Ju, Wantong Song, Yu Tao*, Xiaoyuan Chen*, Mingqiang Li*. Anti-phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy. Sci. Adv. 2023, 9, eadh2413.

9. Fangfang Cao, Yanjuan Sang, Chaoying Liu*, Fuquan Bai, Lirong Zheng, Jinsong Ren*, Xiaogang Qu*. Self-adaptive single-atom catalyst boosting selective ferroptosis in tumor cells. ACS Nano 2022, 16, 855. (Highly cited paper)

10. Fangfang Cao, Enguo Ju, Yan Zhang, Zhenzhen Wang, Chaoqun Liu, Wei Li, Yanyan Huang, Kai Dong, Jinsong Ren*, and Xiaogang Qu*. An efficient and benign antimicrobial depot based on silver-infused MoS₂. ACS Nano 2017, 11, 4651.

11. Fangfang Cao. In vitro nanomaterial testing: unveiling biases through biomolecular corona influence. Nanoscale Horiz. 2024, 9, 1070. (Editorial, Invited)

12. Fangfang Cao, Yan Zhang, Yuhuan Sun, Zhenzhen Wang, Lu Zhang, Yanyan Huang, Chaoqun Liu, Zhen Liu, Jinsong Ren*, Xiaogang Qu*. Ultrasmall nanozymes isolated within porous carbonaceous frameworks for synergistic cancer therapy: enhanced oxidative damage and reduced energy supply. Chem. Mater. 2018, 30, 7831.

13. Fangfang Cao, Enguo Ju, Chaoqun Liu, Wei Li, Yan Zhang, Kai Dong, Zhen Liu, Jinsong Ren*, Xiaogang Qu*. Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release. Nanoscale 2017, 9, 4128.

14. Fangfang Cao, Enguo Ju, Chaoqun Liu, Fang Pu*, Jinsong Ren*, Xiaogang Qu*. Coupling a DNA-ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols. Chem. Commun. 2016, 52, 5167.

15. Kai Dong, Wenbo Lin, Tianyu Zhu, Shuwen Sun, Chenhao Zhang, Chen Xu*, Fangfang Cao*, Xiaoyuan Chen*. NIR-actuated botanicals/nanozymes nanofibrous membranes for antibiotic-free triple-synergistic therapy against polymicrobial wound infections. Adv. Healthcare Mater. 2024, 2401657. (Invited)

16. Yanlin Feng^†, Xin Ning^†, Jianlin Wang, Zhaoyang Wen, Fangfang Cao*, Qing You, Jianhua Zou, Xin Zhou, Teng Sun, Jimin Cao*, Xiaoyuan Chen*. Mace-like plasmonic Au-Pd heterostructures boost near-infrared photoimmunotherapy. Adv. Sci. 2023,10, 2204842.

17. Yanlin Feng^†, Jianlin Wang^†, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao*, Xiaoyuan Chen*, Jimin Cao*. BaTiO₃@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism. Nano. Res. 2023, 16, 2775.

18. Yanlin Feng^†, Jianlin Wang^†, Jimin Cao*, Fangfang Cao*, Xiaoyuan Chen*, Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy. Exploration 2024, 4, 20230019. (Invited)

19. Xinyang Yu^†, Shaolong Qi^†, Fangfang Cao^†, Kai Yang, Hongjian Li, Kun Peng, Zhida Liu*, Bing Bai, Marija Buljan*, Xiaoyuan Chen*, Guocan Yu*. Fabrication of an immunostimulatory supramolecular nanomedicine for potent cancer chemoimmunotherapy. JACS Au 2023, 3, 3181.

专利

1. 曹芳芳; 毛峥伟; 陈小元; 一种提高肠道益生菌在口服递送过程中存活率的方法, 2023-11-3, 中国, ZL202111205961.2.

2. Xiaoyuan Chen; Zhengwei Mao; Fangfang Cao; Artificial Enzyme-Bacteria System and Uses Thereof, 2023-3-9, WIPO, PCT/SG2022/050638.

3. 陈小元; 毛峥伟; 曹芳芳; 一种可靶向肠道肿瘤的抗癌复合物及其制备方法和应用, 2024-09-24, 中国, ZL202111178378.7.

学术兼职

Community Board Member of Nanoscale Horizons (2023)

科研项目

1. 2023年 新加坡卫生部青年基金，OFYIRG23jul-0013，Artificial enzyme-regulated probiotics for self-adaptive tumor therapy，SGD 325,000, 约人民币170万（主持）。

2. 2024年  国家自然科学基金优秀青年科学基金项目（海外），国家自然科学基金委员会（NSFC）（主持）。

报告

1. 2024年12月 重庆医科大学2024年科技创新与人才工作大会 （邀请报告）

2. 2024年11月 纳米生物学与纳米生物材料2024年崖州会议 （邀请报告）

3. 2024年6月 广州医科大学生物医学工程学院之“康复工程创新论坛”系列讲座（十九）（邀请报告）

4. 2024年6月 中国化学会第34届学术年会(口头报告)

5. 2024年5月 第四届中国微米纳米技术学会微纳米技术与医疗健康创新大会 (口头报告)

6. 2023年8月 ChinaNANO 2023, 9th International Conference on Nanoscience and Technology, Beijing, China (邀请报告)

7. 2023年2月 清华大学（邀请报告）